K
Karen A. Brown
Researcher at Montreal Children's Hospital
Publications - 91
Citations - 3075
Karen A. Brown is an academic researcher from Montreal Children's Hospital. The author has contributed to research in topics: Obstructive sleep apnea & Sleep apnea. The author has an hindex of 23, co-authored 88 publications receiving 2774 citations. Previous affiliations of Karen A. Brown include McGill University & McGill University Health Centre.
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Journal ArticleDOI
Planning Adenotonsillectomy in Children With Obstructive Sleep Apnea: The Role of Overnight Oximetry
Gillian M. Nixon,Andrea S. Kermack,G. Michael Davis,John J. Manoukian,Karen A. Brown,Robert T. Brouillette +5 more
TL;DR: Overnight pulse oximetry can be used to estimate the severity of OSA, to shorten the diagnostic and treatment process for those with more severe disease, and to aid clinicians in prioritization of T&A and planning perioperative care.
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Recurrent Hypoxemia in Children Is Associated with Increased Analgesic Sensitivity to Opiates
TL;DR: Previous recurrent hypoxemia in OSA is associated with increased analgesic sensitivity to subsequent morphine administration, and opiate dosing in children with OSA must take into account a history of recurrent Hypoxemia.
Journal ArticleDOI
Interrupter resistance elucidated by alveolar pressure measurement in open-chest normal dogs
Jason H. T. Bates,Mara S. Ludwig,P. D. Sly,Karen A. Brown,James G. Martin,Jeffrey J. Fredberg +5 more
TL;DR: It is found that, in the absence of the chest wall, delta Pinit reflects only the resistance of the airways and that delta Pdif can be ascribed almost entirely to the stress recovery properties of lung tissues.
Journal ArticleDOI
Can assessment for obstructive sleep apnea help predict postadenotonsillectomy respiratory complications
TL;DR: The data suggest, but do not prove, that preoperative nocturnal oximetry could be a useful preoperative test to identify children who are at increased risk for postoperative respiratory complications.
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Recurrent hypoxemia in young children with obstructive sleep apnea is associated with reduced opioid requirement for analgesia.
TL;DR: The authors speculate that the reduced morphine requirement for analgesia in children displaying oxygen desaturation associated with severe OSA may be related to their young age and to an up-regulation of central opioid receptors consequent to recurrent hypoxemia.