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Karen C. Peebles
Researcher at University of Otago
Publications - 47
Citations - 1332
Karen C. Peebles is an academic researcher from University of Otago. The author has contributed to research in topics: Cerebral blood flow & Blood pressure. The author has an hindex of 19, co-authored 43 publications receiving 1198 citations. Previous affiliations of Karen C. Peebles include Macquarie University & University of Auckland.
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Journal ArticleDOI
Human cerebrovascular and ventilatory CO2 reactivity to end‐tidal, arterial and internal jugular vein PCO2
Karen C. Peebles,Leo Anthony Celi,Ken McGrattan,Carissa Murrell,Kate N. Thomas,Philip N. Ainslie +5 more
TL;DR: The hypercapnic and hypocapnic MCAv‐CO2 reactivity was higher (∼97% and ∼24%, respectively) when expressed with P jv,CO 2 than P’s ’a, CO’2 (P < 0.05), indicating that a reduced reactivity results in less central CO2 washout and greater ventilatory stimulus.
Journal ArticleDOI
Assessment of cerebral autoregulation: The quandary of quantification
Yu-Chieh Tzeng,Philip N. Ainslie,William H. Cooke,Karen C. Peebles,Christopher K. Willie,Braid A. MacRae,Jonathan D. Smirl,Helen M. Horsman,Caroline A. Rickards +8 more
TL;DR: It is suggested that only select CA metrics can be used interchangeably and that interpretation of these measures should be done cautiously.
Journal ArticleDOI
Early morning impairment in cerebral autoregulation and cerebrovascular CO2 reactivity in healthy humans: relation to endothelial function.
Philip N. Ainslie,Carissa Murrell,Karen C. Peebles,Marianne Swart,Margot Skinner,Michael J.A. Williams,Robin D. Taylor +6 more
TL;DR: The early morning reduction in cerebral autoregulation may facilitate the onset of cerebrovascular accidents; this may be of particular relevance to at‐risk groups, especially upon resuming the upright position.
Journal ArticleDOI
Alterations in cerebral blood flow and cerebrovascular reactivity during 14 days at 5050 m
Samuel J. E. Lucas,Keith R. Burgess,Kate N. Thomas,Joseph Donnelly,Karen C. Peebles,Rebekah A. I. Lucas,Jui-Lin Fan,James D. Cotter,Rishi Basnyat,Philip N. Ainslie +9 more
TL;DR: The results show that the balance of oxygen (O2) and carbon dioxide (CO2) pressures in arterial blood explains 40% of the change in brain blood flow upon arrival at high altitude (5050 m).
Journal ArticleDOI
Prenatal nicotine exposure increases apnoea and reduces nicotinic potentiation of hypoglossal inspiratory output in mice
Dean M Robinson,Karen C. Peebles,Henry Kwok,Brandon M. Adams,Lan Ling Clarke,Gerald A. Woollard,Gregory D. Funk +6 more
TL;DR: Increased apnoea following nicotine exposure does not appear to reflect changes in basal activity of rhythm or pattern‐generating networks, but may result, in part, from reduced nicotinic modulation of XII motoneurons.