K
Karen L. Anderson
Researcher at Ludwig Institute for Cancer Research
Publications - 3
Citations - 1660
Karen L. Anderson is an academic researcher from Ludwig Institute for Cancer Research. The author has contributed to research in topics: SOD1 & Amyotrophic lateral sclerosis. The author has an hindex of 3, co-authored 3 publications receiving 1594 citations.
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Journal ArticleDOI
Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1.
Lucie Bruijn,Megan K. Houseweart,Shinsuke Kato,Karen L. Anderson,Scott D. Anderson,Eisaku Ohama,Andrew G. Reaume,Rick W. Scott,Don W. Cleveland +8 more
TL;DR: Analysis of transgenic mice expressing familial amyotrophic lateral sclerosis (ALS)-linked mutations in the enzyme superoxide dismutase (SOD1) have shown that motor neuron death arises from a mutant-mediated toxic property or properties, raising the question of whether toxicity arises from superoxide-mediated oxidative stress.
Journal ArticleDOI
Absence of neurofilaments reduces the selective vulnerability of motor neurons and slows disease caused by a familial amyotrophic lateral sclerosis-linked superoxide dismutase 1 mutant.
Toni L. Williamson,Lucie Bruijn,Qinzhang Zhu,Karen L. Anderson,Scott D. Anderson,Jean-Pierre Julien,Don W. Cleveland +6 more
TL;DR: By deleting NF-L, the major neurofilament subunit required for filament assembly, onset and progression of disease caused by familial ALS-linked SOD1 mutant G85R are significantly slowed, while selectivity of mutant-mediated toxicity for motor neurons is reduced.
Journal ArticleDOI
The microtubule-dependent motor centromere-associated protein E (CENP-E) is an integral component of kinetochore corona fibers that link centromeres to spindle microtubules.
TL;DR: Evidence is presented that strongly supports a model in which CENP-E functions in congression to tether kinetochores to the disassembling microtubule plus ends.