Karen L. Smith

TL;DR: The microanatomical features of EGFP-expressing interneurons suggest that they function primarily as “input-biasing” neurons, in that synaptic volleys in stratum radiatum would lead to their activation, which in turn would result in selective suppression of excitatory input from the entorhinal cortex onto CA1 pyramidal cells.

TL;DR: Axonal arbors of CA3C pyramidal cells exhibited normal branching patterns, branching complexity, and varicosity density, which suggests that if deafferentation occurs, synapses other than recurrent excitatory ones are lost.

TL;DR: Anatomical substrates were investigated for local circuit hyperexcitability that occurs in the CA3 subfield of the rat hippocampus and recurrent excitatory axon arbors from single biocytin‐filled CA3 pyramidal cells were reconstructed, showing a significant decrease in all measures of arbor length and complexity.

TL;DR: Results presented here suggest that the sustained depolarization of electrographic seizures is a separate physiological process from the more rapid repetitive depolarizations of the seizure discharges and is required if electrog Graphic seizures are to occur.

TL;DR: The use of the tetanus toxin model in developing rats may facilitate a better understanding of the unique features of epileptogenesis in the developing brain and the consequences early-life seizures have on brain maturation and the genesis of epileptic conditions in later life.