K
Karen S. Chambers
Publications - 2
Citations - 2161
Karen S. Chambers is an academic researcher. The author has contributed to research in topics: Antibody & CD3. The author has an hindex of 2, co-authored 2 publications receiving 2115 citations.
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Depletion of B cells in vivo by a chimeric mouse human monoclonal antibody to CD20
Reff Mitchell E,Kristin Carner,Karen S. Chambers,Paul Chinn,John E Leonard,Ron Raab,Roland A. Newman,Nabil Hanna,Darrell R Anderson +8 more
TL;DR: In vitro studies showed the ability of C2B8 to bind human C1q, mediate complement-dependent cell lysis of human B-lymphoid cell lines, and lyse human target cells through antibody-dependent cellular cytotoxicity and the possibility of using an "immunologically active" chimeric anti-CD20 antibody as an alternative approach in the treatment of B-cell lymphoma.
Journal ArticleDOI
A primatized MAb to human CD4 causes receptor modulation, without marked reduction in CD4+ T cells in chimpanzees: in vitro and in vivo characterization of a MAb (IDEC-CE9.1) to human CD4.
Darrell R Anderson,Karen S. Chambers,Nabil Hanna,John E Leonard,Reff Mitchell E,Roland A. Newman,John Baldoni,Donna Dunleavy,Manjula Reddy,Raymond W. Sweet,Alemseged Truneh +10 more
TL;DR: A Primatized anti-CD4 monoclonal antibody (MAb), CE9.1, with V-domain from cynomolgus macaque, and a human IgG1 constant region, was characterized in vitro and in vivo in chimpanzees, finding that, although there was apparent loss of CD4+ lymphocytes, an equivalent number of CD3+CD8- T lymphocytes were present in circulation in all four chimpanzees treated with 10.0 mg/kg CE