K
Karim Arsalane
Researcher at Université de Sherbrooke
Publications - 1
Citations - 147
Karim Arsalane is an academic researcher from Université de Sherbrooke. The author has contributed to research in topics: Transforming growth factor & Gene expression. The author has an hindex of 1, co-authored 1 publications receiving 140 citations.
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Transforming growth factor-beta1 is a potent inhibitor of glutathione synthesis in the lung epithelial cell line A549: transcriptional effect on the GSH rate-limiting enzyme gamma-glutamylcysteine synthetase.
Karim Arsalane,Claire M. Dubois,Thierry Muanza,Raymond Bégin,François Boudreau,Claude Asselin,André M. Cantin +6 more
TL;DR: It is observed that TGF-β1 increased susceptibility of the human alveolar epithelial cell line A549 to H2O2-mediated cytotoxicity, and decreased the activities of the antioxidant enzymes glutathione reductase and catalase by 31%, and markedly decreased GSH content in A549 cells.