Claude Asselin

TL;DR: It is observed that TGF-β1 increased susceptibility of the human alveolar epithelial cell line A549 to H2O2-mediated cytotoxicity, and decreased the activities of the antioxidant enzymes glutathione reductase and catalase by 31%, and markedly decreased GSH content in A549 cells.

TL;DR: E epithelial HDAC1 and HDAC2 restrain the intestinal inflammatory response, by regulating intestinal epithelial cell proliferation and differentiation, as determined by inflammatory molecular expression signatures and altered inflammatory gene expression.

TL;DR: It is demonstrated, for the first time, that constitutive activation of MEK1 in intestinal epithelial cells is sufficient to induce an EMT associated with tumor invasion and metastasis.

TL;DR: PAF induced a rapid tyrosine phosphorylation of the Tyk2 kinase in the monocytic cell lines U937 and MonoMac-1, suggesting an important role for the Janus kinase/STAT pathway in PAFR signaling, independent of G-proteins, and in the regulation of PAF receptor expression by its ligand.

TL;DR: The results indicate that SHP-1 may be involved in the regulation of β-catenin transcriptional function and in the negative control of intestinal epithelial cell proliferation.