K
Karim Maloum
Researcher at Curie Institute
Publications - 1
Citations - 93
Karim Maloum is an academic researcher from Curie Institute. The author has contributed to research in topics: Apoptosis & Lactacystin. The author has an hindex of 1, co-authored 1 publications receiving 93 citations.
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Deregulation of the ubiquitin system and p53 proteolysis modify the apoptotic response in B-CLL lymphocytes.
TL;DR: It is shown that only specific—not nonspecific—proteasomal inhibitors can discriminate between malignant and normal lymphocytes in inducing the apoptotic death response, and raises the possibility that two different proteolytic pathways controlling p53 stability may be pathologically imbalanced.