K
Karima Chergui
Researcher at Karolinska Institutet
Publications - 57
Citations - 4443
Karima Chergui is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Dopamine & Nucleus accumbens. The author has an hindex of 30, co-authored 52 publications receiving 4221 citations. Previous affiliations of Karima Chergui include University of Birmingham & Centre national de la recherche scientifique.
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Journal ArticleDOI
Alterations in 5-HT1B Receptor Function by p11 in Depression-Like States
Per Svenningsson,Karima Chergui,Ilan Rachleff,Marc Flajolet,Xiaoqun Zhang,Malika El Yacoubi,Jean-Marie Vaugeois,George G. Nomikos,Paul Greengard +8 more
TL;DR: Overexpression of p11 increases 5-HT1B receptor function in cells and recapitulates certain behaviors seen after antidepressant treatment in mice, which contributes to depression-like phenotype and reduced behavioral reactions to an antidepressant.
Journal ArticleDOI
Dopamine and cAMP-Regulated Phosphoprotein 32 kDa Controls Both Striatal Long-Term Depression and Long-Term Potentiation, Opposing Forms of Synaptic Plasticity
Paolo Calabresi,Paolo Gubellini,Diego Centonze,Barbara Picconi,Giorgio Bernardi,Karima Chergui,Per Svenningsson,Allen A. Fienberg,Paul Greengard +8 more
TL;DR: Evidence is provided that the D1-like receptor-dependent activation of DA and cyclic adenosine 3′,5′ monophosphate-regulated phosphoprotein 32 kDa is a crucial step for the induction of both long-term depression (LTD) and long- term potentiation (LTP), two opposing forms of synaptic plasticity.
Journal Article
Neurochemical Characteristics of Amisulpride, an Atypical Dopamine D2/D3 Receptor Antagonist with Both Presynaptic and Limbic Selectivity
Hans Schoemaker,Y. Claustre,Dominique Fage,Liliane Rouquier,Karima Chergui,Olivier Curet,André Oblin,François Gonon,C.J. Carter,Jesus Benavides,Bernard Scatton +10 more
TL;DR: Amisulpride is characterized as a specific dopamine receptor antagonist with high and similar affinity for the dopamine D2 and D3 receptor with a degree of limbic selectivity and a preferential effect, at low doses, on dopamine D 2/D3 autoreceptors.
Journal ArticleDOI
Tonic Activation of NMDA Receptors Causes Spontaneous Burst Discharge of Rat Midbrain Dopamine Neurons In Vivo
Karima Chergui,P. J. Charlety,Hideo Akaoka,Claude Saunier,J.-L. Brunet,Michel Buda,Torgny H. Svensson,Guy Chouvet +7 more
TL;DR: The data suggest that burst‐firing of midbrain dopamine neurons in vivo results from the tonic activation of NMDA receptors by endogenous excitatory amino acids, a major physiological substrate in the control of the dopamine level in target areas.
Journal ArticleDOI
Relationship between dopamine release in the rat nucleus accumbens and the discharge activity of dopaminergic neurons during local in vivo application of amino acids in the ventral tegmental area
TL;DR: Dopaminergic terminals convert physiological impulse flow into dopamine release as a high pass filter which favors bursts of action potentials and N-methyl-D-aspartate was twice as potent as quisqualate.