K
Karl-Heinz Wiesmüller
Researcher at University of Tübingen
Publications - 175
Citations - 6700
Karl-Heinz Wiesmüller is an academic researcher from University of Tübingen. The author has contributed to research in topics: Epitope & MHC class I. The author has an hindex of 44, co-authored 174 publications receiving 6477 citations. Previous affiliations of Karl-Heinz Wiesmüller include Radboud University Nijmegen Medical Centre.
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Journal ArticleDOI
In vivo priming of virus-specific cytotoxic T lymphocytes with synthetic lipopeptide vaccine
TL;DR: It is reported that synthetic viral peptides covalently linked to tripalmitoyl-S-glycerylcysteinyl-seryl-serine (P3CSS) can efficiently prime influenza-virus-specific CTL in vivo and are able to induce the same high-affinity CTL as does the infectious virus.
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Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling.
Katja Farhat,Sabine Riekenberg,Holger Heine,Jennifer Debarry,Roland Lang,Jörg Mages,Ute Buwitt-Beckmann,Kristina Röschmann,Günther Jung,Karl-Heinz Wiesmüller,Artur J. Ulmer +10 more
TL;DR: Heterodimerization of TLR2 with TLR1 or TLR6 evolutionarily developed to expand the ligand spectrum to enable the innate immune system to recognize the numerous, different structures of LP present in various pathogens.
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TLR1- and TLR6-independent recognition of bacterial lipopeptides.
Ute Buwitt-Beckmann,Holger Heine,Karl-Heinz Wiesmüller,Günther Jung,Roland Brock,Shizuo Akira,Artur J. Ulmer +6 more
TL;DR: A triacylation pattern is necessary but not sufficient to render a lipopeptide TLR1-dependent, and a diacylation patterns is necessarybut not sufficientTo render alipopeptides TLR6-dependent.
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Toll-like receptor 6-independent signaling by diacylated lipopeptides.
Ute Buwitt-Beckmann,Holger Heine,Karl-Heinz Wiesmüller,Günther Jung,Roland Brock,Shizuo Akira,Artur J. Ulmer +6 more
TL;DR: The results indicate that both the lipid and the N‐terminal peptides of lipoproteins contribute to the specificity of recognition by TLR2 heteromers and are responsible for the ligand–receptor interaction on host cells.
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Recognition principle of the TAP transporter disclosed by combinatorial peptide libraries
TL;DR: In this article, the authors analyzed the substrate specificity of human TAP at high resolution and in the absence of any given sequence context, revealing the contribution of each peptide residue in stabilizing binding to TAP.