K
Karl Peter Giese
Researcher at King's College London
Publications - 78
Citations - 7447
Karl Peter Giese is an academic researcher from King's College London. The author has contributed to research in topics: Ca2+/calmodulin-dependent protein kinase & Long-term potentiation. The author has an hindex of 38, co-authored 73 publications receiving 6980 citations. Previous affiliations of Karl Peter Giese include École Polytechnique Fédérale de Lausanne & Cold Spring Harbor Laboratory.
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Journal ArticleDOI
Abnormal Hippocampal Spatial Representations in αCaMKIIT286A and CREBαΔ− Mice
Yoon H. Cho,Karl Peter Giese,Karl Peter Giese,Karl Peter Giese,Heikki Tanila,Heikki Tanila,Heikki Tanila,Alcino J. Silva,Alcino J. Silva,Alcino J. Silva,Howard Eichenbaum,Howard Eichenbaum,Howard Eichenbaum +12 more
TL;DR: In this paper, the fine-tuning and stability of place cell firing was compared in two types of mutant mice with different long-term potentiation (LTP) and place learning impairments.
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Mice doubly deficient in the genes for P0 and myelin basic protein show that both proteins contribute to the formation of the major dense line in peripheral nerve myelin
TL;DR: The view that axon caliber is dependent on normal myelin is modified, as mice deficient in the myelin proteins P0 and MBP showed myelin of reduced thickness around axons of normal caliber.
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Reduced K+ channel inactivation, spike broadening, and after-hyperpolarization in Kvbeta1.1-deficient mice with impaired learning.
Karl Peter Giese,Johan F. Storm,Dirk Reuter,Fedorov Nikolai,Li-Rong Shao,Thorsten Leicher,Olaf Pongs,Alcino J. Silva +7 more
TL;DR: The deletion of the Kvbeta1.1 gene in mice resulted in a reduced K+ current inactivation in hippocampal CA1 pyramidal neurons and frequency-dependent spike broadening and the slow afterhyperpolarization (sAHP) were reduced, which suggests that Kv beta1.
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Hippocampus-dependent learning and memory is impaired in mice lacking the Ras-guanine-nucleotide releasing factor 1 (Ras-GRF1).
Karl Peter Giese,Eugenia Friedman,Jean-Baptiste Telliez,Fedorov Nikolai,Mary Wines,Larry A. Feig,Alcino J. Silva +6 more
TL;DR: Inactivated Ras-GRF1 gene in mice indicates that Ras- GRF1 plays a role in hippocampal-dependent learning and memory.
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Calcium/calmodulin-dependent kinase II and Alzheimer's disease.
Anshua Ghosh,Karl Peter Giese +1 more
TL;DR: The hypothesis that changes in CaMKII dysregulation critically contribute to neurodegeneration and memory impairment in Alzheimer’s disease is put forward.