K
Karl Whitney
Researcher at Research Triangle Park
Publications - 18
Citations - 1883
Karl Whitney is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Liver X receptor & Glutamate receptor. The author has an hindex of 14, co-authored 18 publications receiving 1802 citations. Previous affiliations of Karl Whitney include GlaxoSmithKline & The New School.
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Journal ArticleDOI
Identification of a Nonsteroidal Liver X Receptor Agonist through Parallel Array Synthesis of Tertiary Amines
Jon L. Collins,Adam M. Fivush,Michael A. Watson,Cristin M. Galardi,Michael C. Lewis,Linda B. Moore,Derek J. Parks,Joan G. Wilson,Tim K. Tippin,Jane G Binz,Kelli D. Plunket,Daniel G Morgan,Elizabeth J. Beaudet,Karl Whitney,Steven A. Kliewer,Timothy M. Willson +15 more
TL;DR: A potent, selective, orally active LXR agonist was identified from focused libraries of tertiary amines and will be a valuable chemical tool to investigate the role of LXR in the regulation of reverse cholesterol transport and lipid metabolism.
Journal ArticleDOI
Developmental neurotoxicity of chlorpyrifos: cellular mechanisms.
TL;DR: The results indicate that low doses of chlorpyrifos target the developing brain during the critical period in which cell division is occurring, effects which may produce eventual cellular, synaptic, and behavioral aberrations after repeated or prolonged subtoxic exposures.
Journal ArticleDOI
Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system
Karl Whitney,Michael A. Watson,Jon L. Collins,William G. Benson,Tammy M. Stone,Mary Jo Numerick,Timothy K. Tippin,Joan G. Wilson,Deborah A. Winegar,Steven A. Kliewer +9 more
TL;DR: It is shown that LXR agonists have marked effects on gene expression in murine brain tissue both in vitro and in vivo, and this data provides the first evidence that the LXRs regulate cholesterol homeostasis in the central nervous system.
Journal ArticleDOI
Early Bactericidal Activity and Pharmacokinetics of PA-824 in Smear-Positive Tuberculosis Patients
Andreas H. Diacon,Rodney Dawson,Madeleine Hanekom,Kim Narunsky,Stefan J. Maritz,Amour Venter,Peter R. Donald,Christo van Niekerk,Karl Whitney,Doris J. Rouse,Martino W. Laurenzi,Ann M. Ginsberg,Melvin Spigelman +12 more
TL;DR: It is concluded that PA-824 demonstrated bactericidal activity over the dose range of 200 to 1,200 mg daily over 14 days, and maximum efficacy was unexpectedly achieved at the lowest dosage tested.
Journal ArticleDOI
Liver X Receptor (LXR) Regulation of the LXRα Gene in Human Macrophages
Karl Whitney,Michael A. Watson,Bryan Goodwin,Cristin M. Galardi,Jodi M. Maglich,Joan G. Wilson,Timothy M. Willson,Jon L. Collins,Steven A. Kliewer +8 more
TL;DR: It is reported that natural and synthetic LXR ligands induce the expression of the LXRα gene in primary human macrophages and differentiated THP-1 macrophage and that this response is likely to amplify the effects of oxysterols on reverse cholesterol transport.