K
Karla Kirkegaard
Researcher at Stanford University
Publications - 111
Citations - 16652
Karla Kirkegaard is an academic researcher from Stanford University. The author has contributed to research in topics: RNA & RNA-dependent RNA polymerase. The author has an hindex of 55, co-authored 107 publications receiving 15555 citations. Previous affiliations of Karla Kirkegaard include Massachusetts Institute of Technology & Harvard University.
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Variant enterovirus A71 found in immune-suppressed patient binds to heparan sulfate and exhibits neurotropism in B-cell-depleted mice.
Kuo-Feng Weng,Han Kang Tee,Eirini D. Tseligka,Valeria Cagno,Gregory Mathez,Claude M. Nagamine,Peter Sarnow,Karla Kirkegaard,Caroline Tapparel +8 more
TL;DR: In this paper , the authors show that a leucine-to-arginine substitution on the VP1 capsid protein increases the virus's pathogenicity in orally infected mice with depleted B cells.