Karlheinz Mann

TL;DR: In this paper, the shape of the nidogen was shown to be a three globes of variable mass (31-56 kDa) connected by either a rod-like or a thin segment, indicating that the Nterminal domain of the more native, recombinant protein consists of two globules connected by a flexible segment.

TL;DR: It is demonstrated that proteolytic release of endostatin can occur through several pathways, which may lead to a switch from a matrix‐associated to a more soluble endocrine form.

TL;DR: Eggshell microstructure and ultrastructure is reviewed, and the results of recent genomic, transcriptomic and proteomic analyses of the chicken eggshell matrix are reviewed to draw attention to areas of current uncertainty such as the potential role of amorphous calcium carbonate.

TL;DR: Data show that, although vascular endothelial growth factor expression is elevated in chronic wounds, increased proteolytic activity in this environment results in its degradation, which may contribute to an impaired wound healing response.

TL;DR: Smaller fragments were prepared by the same recombinant procedure and showed that combinations of EGF‐like repeats 3–4 and 4–5 and the single repeat 4 but not repeats 3 or 5 possess full nidogen‐binding activity, identifying repeat 4 as the only binding structure.