K
Karolyn M. Hansen
Researcher at University of Dayton
Publications - 21
Citations - 2194
Karolyn M. Hansen is an academic researcher from University of Dayton. The author has contributed to research in topics: Optical fiber & Fiber optic sensor. The author has an hindex of 12, co-authored 21 publications receiving 2128 citations. Previous affiliations of Karolyn M. Hansen include Oak Ridge National Laboratory & University of Dayton Research Institute.
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Journal ArticleDOI
Bioassay of prostate-specific antigen (PSA) using microcantilevers.
TL;DR: It is reported here that microcantilevers of different geometries have been used to detect two forms of prostate-specific antigen over a wide range of concentrations from 0.2 ng/ml to 60 μg/ml in a background of human serum albumin and human plasminogen at 1 mg/ml, making this a clinically relevant diagnostic technique for prostate cancer.
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Origin of nanomechanical cantilever motion generated from biomolecular interactions.
Guanghua Wu,Hai-Feng Ji,Karolyn M. Hansen,Thomas Thundat,Ram H. Datar,Richard J. Cote,Michael F. Hagan,Arup K. Chakraborty,Arunava Majumdar +8 more
TL;DR: The origin of motion lies in the interplay between changes in configurational entropy and intermolecular energetics induced by specific biomolecular interactions, and by controlling entropy change during DNA hybridization, the direction of cantilever motion can be manipulated.
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Cantilever-based optical deflection assay for discrimination of DNA single-nucleotide mismatches.
Karolyn M. Hansen,Hai-Feng Ji,Guanghua Wu,Ram H. Datar,Richard J. Cote,and Arunava Majumdar,Thomas Thundat +6 more
TL;DR: The discrimination of DNA mismatches is demonstrated using an elegantly simple microcantilever-based optical deflection assay, without the need for external labeling, that is readily adaptable to a high-throughput array format and provides a distinct positive/negative signal for easy interpretation of oligonucleotide hybridization.
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Detection of pH variation using modified microcantilever sensors
TL;DR: In this paper, a micromechanical technique for measuring solution pH using modified silicon (SiO2) and silicon nitride (Si3N4) microcantilevers is described.
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Cellular orchestrated biomineralization of crystalline composites on implant surfaces by the eastern oyster, Crassostrea virginica (Gmelin, 1791)
Mary Beth Johnstone,Neeraj V. Gohad,E.P. Falwell,Douglas C. Hansen,Karolyn M. Hansen,Andrew S. Mount +5 more
TL;DR: It is proposed that molluscan shell is formed through a series of coordinated events involving cells and cell products whereby both organic and mineral phases are secreted, organized, and simultaneously formed.