K
Karthik Venkatakrishnan
Researcher at Takeda Pharmaceutical Company
Publications - 187
Citations - 7883
Karthik Venkatakrishnan is an academic researcher from Takeda Pharmaceutical Company. The author has contributed to research in topics: Pharmacokinetics & Population. The author has an hindex of 45, co-authored 162 publications receiving 7195 citations. Previous affiliations of Karthik Venkatakrishnan include Orlando Regional Medical Center & Merck Serono.
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Journal ArticleDOI
Effects of the antifungal agents on oxidative drug metabolism: clinical relevance.
Karthik Venkatakrishnan,L L von Moltke,L L von Moltke,David J. Greenblatt,David J. Greenblatt +4 more
TL;DR: The interactions of ketoconazole with cyclosporin and tacrolimus have been applied for therapeutic purposes to allow a lower dosage and cost of the immunosuppressant and a reduced risk of fungal infections.
Journal ArticleDOI
The impact of p-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the mdr1a/ 1b knockout mouse model
Angela C. Doran,R. Scott Obach,Bill J. Smith,Natilie Hosea,Stacey L. Becker,Ernesto Callegari,Cuiping Chen,Xi Chen,Edna F. Choo,Julie Cianfrogna,Loretta M. Cox,John P. Gibbs,Megan A. Gibbs,Heather L. Hatch,Cornelis E. C. A. Hop,Ilana N. Kasman,Jennifer L. LaPerle,JianHua Liu,Xingrong Liu,Michael J. Logman,Debra Maclin,Frank M. Nedza,Frederick R. Nelson,Emily R. Olson,Sandhya Rahematpura,David Raunig,Sabrinia Rogers,Kari Schmidt,Douglas K. Spracklin,Mark A. Szewc,Matthew D. Troutman,Elaine E. Tseng,Meihua Tu,Jeffrey Van Deusen,Karthik Venkatakrishnan,Gary Walens,Ellen Q. Wang,Diane Wong,Adam Yasgar,Chenghong Zhang +39 more
TL;DR: It appears that most CNS-active agents demonstrate at least some P-gp-mediated transport that can affect brain concentrations, and unbound plasma concentrations may need to be greater than values projected using receptor affinity data to achieve adequate receptor occupancy for effect.
Journal ArticleDOI
Mechanism-based inactivation of human cytochrome p450 enzymes and the prediction of drug-drug interactions.
TL;DR: P450 in vitro inactivation data are valuable in predicting clinical DDIs that can occur via this mechanism, and an approach that can be used with greater throughput was developed.
Journal ArticleDOI
The Utility of in Vitro Cytochrome P450 Inhibition Data in the Prediction of Drug-Drug Interactions
R. Scott Obach,Robert L. Walsky,Karthik Venkatakrishnan,Emily A. Gaman,J. Brian Houston,Larry M. Tremaine +5 more
TL;DR: Findings support the conclusion that P450 in vitro inhibition data are valuable in designing clinical DDI study strategies and can be used to predict the magnitudes of DDI.
Journal Article
CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants.
Leah M. Hesse,Karthik Venkatakrishnan,Michael H. Court,Lisa L. von Moltke,Su Xiang Duan,Richard I. Shader,David J. Greenblatt +6 more
TL;DR: Bupropion hydroxylation is mediated almost exclusively by CYP2B6 and can serve as an index reaction reflecting activity of this isoform and suggest a low inhibitory potency versus CYP 2D6, the clinical importance of which is not established.