K
Katherine E. Deigan
Researcher at University of North Carolina at Chapel Hill
Publications - 3
Citations - 768
Katherine E. Deigan is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Nucleic acid structure & RNA. The author has an hindex of 3, co-authored 3 publications receiving 690 citations.
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Accurate SHAPE-directed RNA structure determination
TL;DR: It is demonstrated that quantitative, nucleotide-resolution information from a SHAPE experiment can be interpreted as a pseudo-free energy change term and used to determine RNA secondary structure with high accuracy, comparable to the best accuracies achievable by comparative sequence analysis.
Journal ArticleDOI
Influence of nucleotide identity on ribose 2′-hydroxyl reactivity in RNA
Kevin A. Wilkinson,Suzy M. Vasa,Katherine E. Deigan,Stefanie Mortimer,Morgan C. Giddings,Kevin M. Weeks +5 more
TL;DR: It is shown that guanosine and adenosine residues have identical intrinsic 2'-hydroxyl reactivities at pH 8.0 and are 1.4 and 1.7 times more reactive than uridine and cytidine, respectively.