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Stefanie Mortimer
Researcher at University of California, Berkeley
Publications - 45
Citations - 3503
Stefanie Mortimer is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: RNA & Cancer. The author has an hindex of 20, co-authored 43 publications receiving 2899 citations. Previous affiliations of Stefanie Mortimer include University of North Carolina at Chapel Hill & Lawrence Berkeley National Laboratory.
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Journal ArticleDOI
Analytical and clinical validation of a digital sequencing panel for quantitative, highly accurate evaluation of cell-free circulating tumor DNA
Richard B. Lanman,Stefanie Mortimer,Oliver A. Zill,Dragan Sebisanovic,Rene Lopez,Sibel Blau,Eric A. Collisson,Stephen G. Divers,Dave S.B. Hoon,E. Scott Kopetz,Jeeyun Lee,Petros Nikolinakos,Arthur Baca,Bahram G. Kermani,Helmy Eltoukhy,Amir Ali Talasaz +15 more
TL;DR: The analytic and clinical validation of the gene panel are reported and near-perfect analytic specificity enables complete coverage of many genes without the false positives typically seen with traditional sequencing assays at mutant allele frequencies or fractions below 5%.
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Insights into RNA structure and function from genome-wide studies
TL;DR: This Review discusses the emerging relationships between RNA structure and the regulation of gene expression and reveals how RNA structure affects each step of protein expression and RNA stability.
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Multiplexed RNA structure characterization with selective 2′-hydroxyl acylation analyzed by primer extension sequencing (SHAPE-Seq)
Julius B. Lucks,Stefanie Mortimer,Cole Trapnell,Cole Trapnell,Shujun Luo,Sharon Aviran,Gary P. Schroth,Lior Pachter,Jennifer A. Doudna,Jennifer A. Doudna,Adam P. Arkin,Adam P. Arkin +11 more
TL;DR: The ability of SHAPE-Seq to accurately infer secondary and tertiary structural information, detect subtle conformational changes due to single nucleotide point mutations, and simultaneously measure the structures of a complex pool of different RNA molecules is demonstrated.
Journal ArticleDOI
A fast-acting reagent for accurate analysis of RNA secondary and tertiary structure by SHAPE chemistry.
Stefanie Mortimer,Kevin M. Weeks +1 more
TL;DR: A significantly more useful, fast-acting, reagent for SHAPE chemistry is designed and evaluated that both reacts significantly more rapidly with RNA to form 2‘-O-adducts and is also more labile toward advantageous, self-limiting, hydrolysis.
Journal ArticleDOI
Validation of a Plasma-Based Comprehensive Cancer Genotyping Assay Utilizing Orthogonal Tissue- And Plasma-Based Methodologies
Justin I. Odegaard,John J. Vincent,Stefanie Mortimer,James V. Vowles,Bryan C. Ulrich,Kimberly C. Banks,Stephen R. Fairclough,Oliver A. Zill,Marcin Sikora,Reza Bayat Mokhtari,Diana Abdueva,Rebecca J. Nagy,Christine E. Lee,Lesli A. Kiedrowski,Cloud P. Paweletz,Helmy Eltoukhy,Richard B. Lanman,Darya Chudova,AmirAli Talasaz +18 more
TL;DR: High concordance with orthogonal clinical plasma- and tissue-based genotyping methods supports the clinical accuracy of digital sequencing across all four types of targetable genomic alterations.