K
Kathryn E. Erkkila
Researcher at California Institute of Technology
Publications - 3
Citations - 1881
Kathryn E. Erkkila is an academic researcher from California Institute of Technology. The author has contributed to research in topics: DNA & Ligand (biochemistry). The author has an hindex of 3, co-authored 3 publications receiving 1826 citations.
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Journal ArticleDOI
Recognition and reaction of metallointercalators with DNA.
TL;DR: A more complete understanding of how to target DNA sites with specificity will lead not only to novel chemotherapeutics but also to a greatly expanded ability for chemists to probe DNA and to develop highly sensitive diagnostic agents.
Journal ArticleDOI
Structure of a photoactive rhodium complex intercalated into DNA.
Clara L. Kielkopf,Kathryn E. Erkkila,Brian P. Hudson,Brian P. Hudson,Jacqueline K. Barton,Douglas C. Rees +5 more
TL;DR: The 1.2 Å resolution crystal structure of a sequence-specific rhodium intercalator bound to a DNA helix provides a rationale for the sequence specificity of rhodia intercalators and explains how intercalation in the center of an oligonucleotide modifies DNA conformation.
Journal ArticleDOI
Recognition and Reaction of Metallointercalators with DNA
TL;DR: The design of small complexes that bind and react at specific sequences of DNA becomes important as we begin to delineate, on a molecular level, how genetic information is expressed.