D
Duncan T. Odom
Researcher at University of Cambridge
Publications - 127
Citations - 24419
Duncan T. Odom is an academic researcher from University of Cambridge. The author has contributed to research in topics: Transcription factor & Gene. The author has an hindex of 58, co-authored 124 publications receiving 22123 citations. Previous affiliations of Duncan T. Odom include Massachusetts Institute of Technology & Medical Research Council.
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Journal ArticleDOI
Transcriptional Regulatory Networks in Saccharomyces cerevisiae
Tong Ihn Lee,Nicola J. Rinaldi,François Robert,Duncan T. Odom,Ziv Bar-Joseph,Georg K. Gerber,Nancy M. Hannett,Christopher T. Harbison,Craig M. Thompson,Itamar Simon,Julia Zeitlinger,Ezra G. Jennings,Heather L. Murray,D. Benjamin Gordon,Bing Ren,John J. Wyrick,Jean-Bosco Tagne,Thomas L. Volkert,Ernest Fraenkel,David K. Gifford,Richard A. Young +20 more
TL;DR: This work determines how most of the transcriptional regulators encoded in the eukaryote Saccharomyces cerevisiae associate with genes across the genome in living cells, and identifies network motifs, the simplest units of network architecture, and demonstrates that an automated process can use motifs to assemble a transcriptional regulatory network structure.
Journal ArticleDOI
Control of developmental regulators by Polycomb in human embryonic stem cells.
Tong Ihn Lee,Richard G. Jenner,Laurie A. Boyer,Matthew G. Guenther,Stuart S. Levine,Roshan M. Kumar,Brett Chevalier,Sarah E. Johnstone,Megan F. Cole,Kyoichi Isono,Haruhiko Koseki,Takuya Fuchikami,Kuniya Abe,Heather L. Murray,Jacob P. Zucker,Bingbing Yuan,George W. Bell,Elizabeth Herbolsheimer,Nancy M. Hannett,Kaiming Sun,Duncan T. Odom,Arie P. Otte,Thomas L. Volkert,David P. Bartel,Douglas A. Melton,David K. Gifford,David K. Gifford,Rudolf Jaenisch,Richard A. Young +28 more
TL;DR: It is found that PRC2 target genes are preferentially activated during ES cell differentiation and that the ES cell regulators OCT4, SOX2, and NANOG cooccupy a significant subset of these genes.
Journal ArticleDOI
Recognition and reaction of metallointercalators with DNA.
TL;DR: A more complete understanding of how to target DNA sites with specificity will lead not only to novel chemotherapeutics but also to a greatly expanded ability for chemists to probe DNA and to develop highly sensitive diagnostic agents.
Journal ArticleDOI
Control of Pancreas and Liver Gene Expression by HNF Transcription Factors
Duncan T. Odom,Nora Zizlsperger,D. Benjamin Gordon,George W. Bell,Nicola J. Rinaldi,Heather L. Murray,Tom L. Volkert,Jörg Schreiber,P. Alexander Rolfe,David K. Gifford,Ernest Fraenkel,Graeme I. Bell,Richard A. Young +12 more
TL;DR: This work used chromatin immunoprecipitation combined with promoter microarrays to identify systematically the genes occupied by the transcriptional regulators HNF1α, HNF4α, and HNF6, together with RNA polymerase II, in human liver and pancreatic islets.
Journal ArticleDOI
Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues
Xinmin Zhang,Duncan T. Odom,Seung Hoi Koo,Michael D. Conkright,Gianluca Canettieri,Jennifer L. Best,Huaming Chen,Richard G. Jenner,Elizabeth Herbolsheimer,Elisabeth Jacobsen,Shilpa Kadam,Joseph R. Ecker,Beverly M. Emerson,John B. Hogenesch,Terry G. Unterman,Richard A. Young,Marc Montminy +16 more
TL;DR: The results indicate that CREB phosphorylation alone is not a reliable predictor of target gene activation and that additional CREB regulatory partners are required for recruitment of the transcriptional apparatus to the promoter.