K
Katrien Van Bocxlaer
Researcher at Hull York Medical School
Publications - 6
Citations - 134
Katrien Van Bocxlaer is an academic researcher from Hull York Medical School. The author has contributed to research in topics: Cutaneous leishmaniasis & Leishmaniasis. The author has an hindex of 3, co-authored 6 publications receiving 70 citations. Previous affiliations of Katrien Van Bocxlaer include University College London & University of London.
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Journal ArticleDOI
Leishmaniasis immunopathology-impact on design and use of vaccines, diagnostics and drugs.
TL;DR: The complexity and variation of immune responses and immunopathology in humans and the different host interactions of the different Leishmania species has an impact upon the effectiveness of vaccines, diagnostics and drugs.
Journal ArticleDOI
Topical formulations of miltefosine for cutaneous leishmaniasis in a BALB/c mouse model.
TL;DR: Miltefosine is the only oral treatment available to treat CL, given over a period of 28 days with common side effects such as vomiting and diarrhoea.
Journal ArticleDOI
Characterization of a new Leishmania major strain for use in a controlled human infection model.
Helen Ashwin,Jovana Sadlova,Barbora Vojtkova,Tomas Becvar,Patrick Lypaczewski,Eli Schwartz,Elizabeth Greensted,Katrien Van Bocxlaer,Marion Pasin,Kai S. Lipinski,Vivak Parkash,Greg Matlashewski,Alison M. Layton,Charles J.N. Lacey,Charles L. Jaffe,Petr Volf,Paul M. Kaye +16 more
TL;DR: In this paper, the authors describe the isolation, characterization and GMP manufacture of a new clinical strain of leishmania major from Israel, which was initially compared by genome sequencing, in vivo infectivity and drug sensitivity in mice and development and transmission competence in sand flies, allowing one to be selected for GMP production.
Posted ContentDOI
Characterization of a new Leishmania major isolate for use in a controlled human infection model
Helen Ashwin,Jovana Sadlova,Barbora Vojtkova,Tomas Becvar,Patrick Lypaczewski,Eli Schwartz,Elizabeth Greensted,Katrien Van Bocxlaer,Marion Pasin,Kai S. Lipinski,Vivak Parkash,Greg Matlashewski,Alison M. Layton,Charles J.N. Lacey,Charles L. Jaffe,Petr Volf,Paul M. Kaye +16 more
TL;DR: This study addresses a major roadblock in the development of vaccines for leish maniasis, providing a key resource for CHIM studies of sand fly transmitted cutaneous leishmaniasis.
Journal ArticleDOI
Film-Forming Systems for the Delivery of DNDI-0690 to Treat Cutaneous Leishmaniasis.
Katrien Van Bocxlaer,Kerri-Nicola McArthur,Andrew G. Harris,Mo Alavijeh,Stéphanie Braillard,Charles E. Mowbray,Simon L. Croft +6 more
TL;DR: In this article, the authors investigated the use of film-forming systems for the delivery of DNDI-0690, a nitroimidazole compound with potent activity against cutaneous leishmaniasis (CL)-causing Leishmania species.