Katsuhiko Uesaka

TL;DR: This study found that adjuvant chemotherapy with S-1 can be a new standard care for resected pancreatic cancer in Japanese patients and estimated overall and relapse-free survival using the Kaplan-Meier methods and assessed non-inferiority of S-2 to gemcitabine using the Cox proportional hazard model.

TL;DR: Curative resection after aggressive preoperative management is recommended as a reasonable surgical approach to hilar cholangiocarcinoma.

TL;DR: Gross portal vein invasion has a negative impact on survival, and hepatectomy with portal vein resection can offer long-term survival in some patients with advanced hilar cholangiocarcinoma, however, the distance between tumor and adventitia is so narrow that curative resection without portal veins resection is unlikely to be possible.

TL;DR: The fact that long-term survival is possible despite pN2 or pM1 disease encourages the authors to perform an aggressive surgical procedure with extended lymph node dissection in selected patients with hilar cholangiocarcinoma.

TL;DR: The pattern of infiltration at the proximal border of resected hilar bile duct carcinomas is closely related to the gross tumor type and the length of submucosal extension is usually less than 10 mm.