K
Katsumi Iizuka
Researcher at Gifu University
Publications - 74
Citations - 2846
Katsumi Iizuka is an academic researcher from Gifu University. The author has contributed to research in topics: Carbohydrate-responsive element-binding protein & Diabetes mellitus. The author has an hindex of 20, co-authored 64 publications receiving 2485 citations. Previous affiliations of Katsumi Iizuka include Gunma University & Osaka University.
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Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis
TL;DR: It is shown that the transcription factor, carbohydrate response element-binding protein (ChREBP), is required both for basal and carbohydrate-induced expression of several liver enzymes essential for coordinated control of glucose metabolism, fatty acid, and the synthesis of fatty acids and triglycerides in vivo.
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Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription
TL;DR: Evidence is provided for a direct and dominant role of ChREBP in the glucose regulation of two key liver lipogenic enzymes, acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS).
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ChREBP: A Glucose-activated Transcription Factor Involved in the Development of Metabolic Syndrome
TL;DR: Results indicate that ChREBP can regulate metabolic gene expression to convert excess carbohydrate into triglyceride rather than glycogen, and reduce the effects of the metabolic syndrome such as obesity, fatty liver, and glucose intolerance.
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Deficiency of carbohydrate-activated transcription factor ChREBP prevents obesity and improves plasma glucose control in leptin-deficient (ob/ob) mice.
TL;DR: It is suggested that inactivation of ChREBP expression not only reduces fat synthesis and obesity in ob/ob mice but also results in improved glucose tolerance and appetite control.
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Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes
TL;DR: Findings suggest that FGF21 expression is regulated by ChREBP, which has beneficial effects of improving the plasma glucose and lipid profiles in diabetic rodents.