K
Kaushlendra Kumar
Researcher at Central Drug Research Institute
Publications - 13
Citations - 373
Kaushlendra Kumar is an academic researcher from Central Drug Research Institute. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 5, co-authored 6 publications receiving 338 citations.
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Journal ArticleDOI
Inhalable Microparticles Containing Large Payload of Anti- tuberculosis Drugs
TL;DR: Microparticles containing large payloads of two anti-tuberculosis drugs were prepared and evaluated for suitability as a dry powder inhalation targeting alveolar macrophages and were deemed suitable for enhanced targeted drug delivery to lung macrophage.
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Intracellular Time Course, Pharmacokinetics, and Biodistribution of Isoniazid and Rifabutin following Pulmonary Delivery of Inhalable Microparticles to Mice
TL;DR: It was concluded that inhaled microparticles can reduce dose frequency and improve the pharmacologic index of the drug combination.
Journal ArticleDOI
A hand-held apparatus for "nose-only" exposure of mice to inhalable microparticles as a dry powder inhalation targeting lung and airway macrophages.
Jatinder Kaur,Pavan Muttil,Rahul Kumar Verma,Kaushlendra Kumar,Awadh Bihari Yadav,Rolee Sharma,Amit Misra +6 more
TL;DR: It is confirmed that inhalation of microparticles targeted airway and lung macrophages and that rifabutin was estimated in serum and tissues of dosed mice by HPLC.
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Partial Biodistribution and Pharmacokinetics of Isoniazid and Rifabutin Following Pulmonary Delivery of Inhalable Microparticles to Rhesus Macaques
Rahul Kumar Verma,Jatinder Kaur Mukker,Ravi Shankar Prasad Singh,Kaushlendra Kumar,Priya Ranjan Prasad Verma,Amit Misra +5 more
TL;DR: The results suggest that human patients would benefit through improvement in biodistribution following DPI, and flip-flop serum pharmacokinetics was observed, and nonlinearity in some pharmacokinetic parameters at logarithmic dose increments was indicated.
Journal ArticleDOI
recA mutations reduce adherence and colonization by classical and El Tor strains of Vibrio cholerae
Kaushlendra Kumar,Ranjana Srivastava,V. B. Sinha,Jane Michalski,James B. Kaper,Brahm S. Srivastava +5 more
TL;DR: Two recA mutants of Vibrio cholerae (classical and El Tor biotypes) were constructed by disruption of the wild-type recA gene with mutated recA sequences of V. Cholerae cloned in the suicide vector pGP704 to study adherence to isolated rabbit intestine and colonization of intestine of infant mice.