K
Kayo Okamura
Researcher at University of Colorado Denver
Publications - 23
Citations - 809
Kayo Okamura is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Acute kidney injury & Lung injury. The author has an hindex of 14, co-authored 19 publications receiving 649 citations. Previous affiliations of Kayo Okamura include Anschutz Medical Campus.
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Journal ArticleDOI
Acute Lung Injury and Acute Kidney Injury Are Established by Four Hours in Experimental Sepsis and Are Improved with Pre, but Not Post, Sepsis Administration of TNF-α Antibodies
Rhea Bhargava,Christopher Altmann,Ana Andres-Hernando,Ryan G. Webb,Kayo Okamura,Yimu Yang,Sandor Falk,Eric P. Schmidt,Sarah Faubel +8 more
TL;DR: ALI and AKI occur together early in the course of sepsis and TNF-α plays a role in the early pathogenesis of both.
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Endocytosis of Albumin by Podocytes Elicits an Inflammatory Response and Induces Apoptotic Cell Death
Kayo Okamura,Patrick D. Dummer,Jeffrey B. Kopp,Liru Qiu,Moshe Levi,Sarah Faubel,Judith Blaine +6 more
TL;DR: An additional mechanism by which anti-proteinuric therapies are beneficial in the treatment of glomerular diseases may be a reduction in injury to the podocyte by albumin, which is strongly associated with progression of chronic kidney disease.
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Heparanase mediates renal dysfunction during early sepsis in mice
Melissa Lygizos,Yimu Yang,Christopher Altmann,Kayo Okamura,Ana Andres Hernando,Mario J. Perez,Lynelle P. Smith,Daniel E. Koyanagi,Aneta Gandjeva,Rhea Bhargava,Rubin M. Tuder,Sarah Faubel,Eric P. Schmidt,Eric P. Schmidt +13 more
TL;DR: It is demonstrated that glomerular heparanase is active during sepsis and contributes to septic renal dysfunction via mechanisms disparate from he paranase‐mediated lung injury.
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Intratracheal IL-6 Protects against Lung Inflammation in Direct, but Not Indirect, Causes of Acute Lung Injury in Mice
Rhea Bhargava,William J. Janssen,Christopher Altmann,Ana Andres-Hernando,Kayo Okamura,R. William Vandivier,Nilesh Ahuja,Sarah Faubel,Sarah Faubel +8 more
TL;DR: IL-6 exerts an anti-inflammatory effect in direct lung injury from IT endotoxin, yet has no role in the pathogenesis or treatment of indirect lung Injury from AKI or IP endotoxin.
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Human podocytes perform polarized, caveolae-dependent albumin endocytosis
TL;DR: The ability of podocytes to endocytose albumin is confirmed and mechanistic insight into cellular mechanisms and fates of albumin handling in podocytes is provided.