K
Kazue Hisaoka-Nakashima
Researcher at Hiroshima University
Publications - 64
Citations - 1182
Kazue Hisaoka-Nakashima is an academic researcher from Hiroshima University. The author has contributed to research in topics: Neuropathic pain & Nociception. The author has an hindex of 19, co-authored 49 publications receiving 920 citations.
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Journal ArticleDOI
Neuropathic Pain in Rats with a Partial Sciatic Nerve Ligation Is Alleviated by Intravenous Injection of Monoclonal Antibody to High Mobility Group Box-1
Yoki Nakamura,Norimitsu Morioka,Hiromi Abe,Fang Fang Zhang,Kazue Hisaoka-Nakashima,Keyue Liu,Masahiro Nishibori,Yoshihiro Nakata +7 more
TL;DR: The results demonstrate that nerve injury evokes the synthesis and release of HMGB1 from spinal neurons, facilitating the activity of both microglia and neurons, which in turn leads to symptoms of neuropathic pain, and could be a useful therapeutic strategy in the treatment of chronic pain.
Journal ArticleDOI
Antidepressant acts on astrocytes leading to an increase in the expression of neurotrophic/growth factors: differential regulation of FGF-2 by noradrenaline
Naoto Kajitani,Kazue Hisaoka-Nakashima,Norimitsu Morioka,Mami Okada-Tsuchioka,Masahiro Kaneko,Miho Kasai,Chiyo Shibasaki,Yoshihiro Nakata,Minoru Takebayashi +8 more
TL;DR: In this paper, the effects of antidepressant treatment on brain-derived neurotrophic factor (FGF-2) and vascular endothelial growth factor (VEGF) were examined using real-time PCR.
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Amitriptyline up-regulates connexin43-gap junction in rat cultured cortical astrocytes via activation of the p38 and c-Fos/AP-1 signalling pathway.
Norimitsu Morioka,K Suekama,Fang Fang Zhang,Naoto Kajitani,Kazue Hisaoka-Nakashima,Minoru Takebayashi,Yoshihiro Nakata +6 more
TL;DR: A potentially novel mechanism of tricyclic antidepressants is to increase the expression and functioning of gap junctions in astrocytes, which is crucial for maintaining CNS homeostasis.
Journal ArticleDOI
Tumor necrosis factor-mediated downregulation of spinal astrocytic connexin43 leads to increased glutamatergic neurotransmission and neuropathic pain in mice.
Norimitsu Morioka,Fang Fang Zhang,Yoki Nakamura,Tomoya Kitamura,Kazue Hisaoka-Nakashima,Yoshihiro Nakata +5 more
TL;DR: Modulation of Cx43 is suggested as a novel target for developing analgesics for neuropathic pain following peripheral nerve injury and the sensitized state following PSNL is likely maintained by dysfunctional glutamatergic neurotransmission.
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History of the G Protein–Coupled Receptor (GPCR) Assays From Traditional to a State-of-the-Art Biosensor Assay
Kanako Miyano,Yuka Sudo,Akinobu Yokoyama,Kazue Hisaoka-Nakashima,Norimitsu Morioka,Minoru Takebayashi,Yoshihiro Nakata,Yoshikazu Higami,Yasuhito Uezono +8 more
TL;DR: The traditional assays are discussed and the principles by which the CellKey™ system evaluates GPCR activation are introduced, followed by a perspective on the advantages and future prospects of this system.