Kazuhiko Sonoyama

TL;DR: It is concluded that adipocytes secrete adiponectin and provide the first functional evidence that it is a physiological modulator of local vascular tone by increasing nitric oxide bioavailability, which is lost in obesity by the development of adipocyte hypertrophy, leading to hypoxia, inflammation, and oxidative stress.

TL;DR: It is observed that when myogenic autoregulation is damaged in the context of hypertension, eutrophic remodeling is replaced by an outward growth of the arterial wall with preservation of lumen diameter, which is a key reason for the unique propensity to hypertensive injury seen in patients with diabetes.

TL;DR: The stage at which diabetic renal disease is most likely to be arrested and even reversed is at the point at which microalbuminuria is detected by the clinician, suggesting an associated reversibility of micro Albuminuria.

TL;DR: It is suggested that, with poor metabolic control, small arteries from patients with type 1 Diabetes mellitus show hypertrophic growth in response to elevated BP, similar to that seen in type 2 diabetes mellitus.

TL;DR: In the NB rat, tissue-specific damage to myogenic tone was associated with progressive proteinuria despite lower blood pressure than the NAs rat, and this is associated with renal damage as manifest by proteinuria.