Kazuhiro Hayashida

TL;DR: Six T cell clones specific for pyruvate dehydrogenase complex (PDC)-E2 peptides from four different patients with primary biliary cirrhosis are established using 33 different peptides of 17-20 amino acid residues corresponding to human PDC-E2 as stimulating antigens, demonstrating the presence of molecular mimicry at the T cell clonal level in human autoimmune diseases.

TL;DR: The high frequency of expression of MAGE-1 gene in HCCs suggests the possibility as a target for tumor-specific immunotherapy for HCC patients.

TL;DR: On the basis of the claim on initiating the case, submitted by twenty Saeima deputies, i.e., Miroslavs Mitrofanovs, Aija Barča, Leons Bojārs, Pēteris Salkazanovs and Jānis Leja, Egils Baldzēns, Aleksandrs Bartaševičs, Andrejs Klementjevs, Jēnis Ādamsons, Pāvels Maksimovs, Jakovs Pliners, Juris Sok

TL;DR: Rat Kupffer cells stimulated with bacterial lipopolysaccharide produced high levels of interleukin 1 (IL‐1), as determined by thymocyte proliferation assay, suggesting that prostaglandin E2 and IL‐1 inhibitor released by K upffer cells may be involved in negative self‐control in regulating IL‐ 1 production and its action.

TL;DR: The HCV virions in the sera of patients with chronic hepatitis C have been shown to be associated simultaneously with immunoglobulins and LDL and/or HDL, but not exclusively, and these lipoprotein binding rates correlated neither to any patient's variables, including the serum apolipoprotein levels, nor to the viral load or the hypervariable region 1 (HVR 1) amino acid sequences.