K
Kazuhiro Higuchi
Researcher at Meiji Pharmaceutical University
Publications - 48
Citations - 1128
Kazuhiro Higuchi is an academic researcher from Meiji Pharmaceutical University. The author has contributed to research in topics: Indole test & Total synthesis. The author has an hindex of 15, co-authored 44 publications receiving 1031 citations.
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Journal ArticleDOI
Simple indole alkaloids and those with a nonrearranged monoterpenoid unit
Tomomi Kawasaki,Kazuhiro Higuchi +1 more
TL;DR: This review covers the literature on simple indole alkaloid and those with a nonrearranged monoterpenoid unit and newly isolated alkaloids, structure determinations, total syntheses and biological activities.
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First total synthesis of hinckdentine A.
Kazuhiro Higuchi,Yukihiro Sato,Mei Tsuchimochi,Kenta Sugiura,Masatoshi Hatori,Tomomi Kawasaki +5 more
TL;DR: The first total synthesis of (+/-)-hinckdentine A is accomplished, followed by acid-mediated Mannich-type C-C bond formation of 2-hydroxyindolin-3-one, seven-membered ring closure, and regioselective tribromination.
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Total syntheses of (-)-fructigenine A and (-)-5-N-acetylardeemin.
Satoshi Takiguchi,Toshimasa Iizuka,Yuh-suke Kumakura,Kohta Murasaki,Naoko Ban,Kazuhiro Higuchi,Tomomi Kawasaki +6 more
TL;DR: The first total synthesis of (-)-fructigenine A and a novel approach to (-)-5-N-acetylardeemin through a common imine intermediate (+)-3 are described.
Journal ArticleDOI
Thionium-based one-pot construction of homo-/heterodimeric pyrroloindoline from tryptamine.
TL;DR: The cyclization of tryptamine with DMSO and Tf(2)O, followed by substitution with indole derivatives, produced racemic 3a-indolylpyrroloindolines.
Journal ArticleDOI
Asymmetric Total Synthesis of (−)-Leuconoxine via Chiral Phosphoric Acid Catalyzed Desymmetrization of a Prochiral Diester
Kazuhiro Higuchi,Shin Suzuki,Reeko Ueda,Norifumi Oshima,Emiko Kobayashi,Masanori Tayu,Tomomi Kawasaki +6 more
TL;DR: The asymmetric total synthesis of (-)-leuconoxine has been achieved and the desymmetrization of a prochiral diester using a chiral phosphoric acid catalyst produced a highly enantioenriched lactam with excellent yield.