https://pubs.rsc.org/en/content/articlepdf/2019/NP/C8NP00092A

Marine natural products.

Stereoselective Addition to N-Activated Pyridines James A. Bull,‡ James J. Mousseau, Guillaume Pelletier,† and Andre ́ B. Charette*,† †Department of Chemistry, Universite ́ de Montreál, P.O. Box 6128, Station Downtown, Montreál, Queb́ec, Canada H3C 3J7 ‡Department of Chemistry, Imperial College London, South Kensington, London SW7 2AZ, U.K. Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA

Synthesis of Pyridine and Dihydropyridine Derivatives by Regio- and Stereoselective Addition to N-Activated Pyridines

Indoles in multicomponent processes (MCPs).

2,5-Diketopiperazines: synthesis, reactions, medicinal chemistry, and bioactive natural products.

A review on recent developments of indole-containing antiviral agents.

Simple indole alkaloids and those with a nonrearranged monoterpenoid unit

First total synthesis of hinckdentine A.

The first total synthesis of (−)-fructigenine A and a novel approach to (−)-5-N-acetylardeemin through a common imine intermediate (+)-3 are described. The key steps include highly enantioselective preparation of (+)-3 via domino olefination/isomerization/Claisen rearrangement (OIC) of 5, reductive cyclization (RC), and regioselective oxidation of (−)-4 and a novel assembly of the pyrazino ring of these alkaloids via Ugi three-component reaction/cyclization of (+)-3 with the corresponding amino acid and isonitrile.

Kazuhiro Higuchi

Papers

Simple indole alkaloids and those with a nonrearranged monoterpenoid unit

First total synthesis of hinckdentine A.

Total syntheses of (-)-fructigenine A and (-)-5-N-acetylardeemin.

Thionium-based one-pot construction of homo-/heterodimeric pyrroloindoline from tryptamine.

Asymmetric Total Synthesis of (−)-Leuconoxine via Chiral Phosphoric Acid Catalyzed Desymmetrization of a Prochiral Diester