K
Kazuhiro Ohtani
Researcher at Kindai University
Publications - 10
Citations - 78
Kazuhiro Ohtani is an academic researcher from Kindai University. The author has contributed to research in topics: Keratan sulfate & Angiotensin II. The author has an hindex of 5, co-authored 10 publications receiving 64 citations.
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Journal ArticleDOI
Activating types 1 and 2 angiotensin II receptors modulate the hypertrophic differentiation of chondrocytes
Ichiro Tsukamoto,Shinji Inoue,Takeshi Teramura,Toshiyuki Takehara,Kazuhiro Ohtani,Masao Akagi +5 more
TL;DR: To examine the role of a local RAS in the hypertrophic differentiation of chondrocytes, angiotensin II type 1 receptor (AT1R) and AT2R were activated separately in the cell line ATDC5, which involves differentiation from mesenchymal stem cells to hypertrophic chondROcytes.
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Interleukin-1 inhibits keratan sulfate production by rabbit chondrocytes: possible role of prostaglandin E2.
TL;DR: The results suggest that IL-1 inhibits KS production, in part, by stimulating the release of PGE2.
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Activation of the renin-angiotensin system in mice aggravates mechanical loading-induced knee osteoarthritis.
Kotaro Yamagishi,Ichiro Tsukamoto,Fumihisa Nakamura,Kazuhiko Hashimoto,Kazuhiro Ohtani,Masao Akagi +5 more
TL;DR: Findings suggest that AT1R expression in chondrocytes is associated with early knee OA and plays a role in the progression of cartilage degeneration and a synergistic effect on JNK phosphorylation was observed between compression loading and AngII addition.
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LOX-1 deficient mice show resistance to zymosan-induced arthritis.
TL;DR: Inflammatory cell infiltration, synovial hyperplasia, and cartilage degeneration were significantly reduced in the LOX-1 KOmice with zymosan-induced arthritis (ZIA) compared to WT mice with ZIA.
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Keratan sulfate inhibits its release in rabbit chondrocyte
TL;DR: Exogenously added KS totally blocks keratanase sensitive glycosaminoglycan release measured by radiolabeled ligand and KS release is potentially inhibited by its own presence as measured by ELISA, suggesting that KS negatively regulates its own secretion.