K
Kazushige Mori
Researcher at Hoffmann-La Roche
Publications - 1
Citations - 647
Kazushige Mori is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Capecitabine & XELIRI. The author has an hindex of 1, co-authored 1 publications receiving 630 citations.
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Preferential activation of capecitabine in tumor following oral administration to colorectal cancer patients.
Johannes Schüller,Jim Cassidy,Etienne Dumont,Brigitte Roos,Sarah Durston,Ludger Banken,Masahiro Utoh,Kazushige Mori,Erhard Weidekamm,Bruno Reigner +9 more
TL;DR: Capecitabine is a novel fluoropyrimidine carbamate rationally designed to generate 5-fluorouracil preferentially in tumors, which is explained to a great extent by the activity of TP in colorectal tumor tissue, (the enzyme responsible for the conversion of 5′-DFUR to 5-FU), which is approximately four times that in adjacent healthy tissue.