K
Kazuyuki Matsushita
Researcher at Chiba University
Publications - 196
Citations - 3590
Kazuyuki Matsushita is an academic researcher from Chiba University. The author has contributed to research in topics: Cancer & Alternative splicing. The author has an hindex of 28, co-authored 182 publications receiving 3043 citations. Previous affiliations of Kazuyuki Matsushita include Kitasato University.
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Journal Article
Overexpression and mistargeting of centromere protein-A in human primary colorectal cancer.
Takeshi Tomonaga,Kazuyuki Matsushita,Seiko Yamaguchi,Tatsuya Oohashi,Hideaki Shimada,Takenori Ochiai,Kinya Yoda,Fumio Nomura +7 more
TL;DR: It is demonstrated that the kinetochore protein CENP-A was overexpressed in all of 11 primary human colorectal cancer tissues, suggesting that overexpression of CENp-A could play an important role for aneuploidy in coloreCTal cancers.
Journal ArticleDOI
Identification of Altered Protein Expression and Post-Translational Modifications in Primary Colorectal Cancer by Using Agarose Two-Dimensional Gel Electrophoresis
Takeshi Tomonaga,Kazuyuki Matsushita,Seiko Yamaguchi,Masamichi Oh-Ishi,Yoshio Kodera,Tadakazu Maeda,Hideaki Shimada,Takenori Ochiai,Fumio Nomura +8 more
TL;DR: Several novel proteins with altered expression in primary colorectal cancer tissues are identified using a high-resolution two-dimensional gel electrophoresis (2-DE) technique to contribute to the deeper understanding of underlying mechanisms of human cancer.
Journal ArticleDOI
Centromere protein H is up-regulated in primary human colorectal cancer and its overexpression induces aneuploidy.
Takeshi Tomonaga,Kazuyuki Matsushita,Masumi Ishibashi,Masahiko Nezu,Hideaki Shimada,Takenori Ochiai,Kinya Yoda,Fumio Nomura +7 more
TL;DR: The results suggest that the aberrant expression and localization of a kinetochore protein CENP-H plays an important role in the aneuploidy frequently observed in colorectal cancers.
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Chemokine gene transfection into tumour cells reduced tumorigenicity in nude mice in association with neutrophilic infiltration.
K. Hirose,M. Hakozaki,Y Nyunoya,Y Kobayashi,Kazuyuki Matsushita,Toshinao Takenouchi,Atsuo Mikata,Naofumi Mukaida,K Matsushima +8 more
TL;DR: Results indicate that chemokines have potent anti-tumour activity when released, even at low doses, at the tumour site, which may be mediated by recruitment and targeting of neutrophilic granulocytes to chemokine-releasing cells.
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Proteomic analysis of primary esophageal squamous cell carcinoma reveals downregulation of a cell adhesion protein, periplakin
Takanori Nishimori,Takeshi Tomonaga,Kazuyuki Matsushita,Masamichi Oh-Ishi,Yoshio Kodera,Tadakazu Maeda,Fumio Nomura,Hisahiro Matsubara,Hideaki Shimada,Takenori Ochiai +9 more
TL;DR: Periplakin, a 195‐kDa protein, was significantly downregulated in esophageal cancer, which was confirmed by immunoblotting and suggested that periplakin could be a useful marker for detection of early esophAGEal cancer and evaluation of tumor progression.