Kees Brinkman

TL;DR: Although the introduction of protease inhibitors has changed management of HIV infection drastically, this cerebro-protective property will assert the role of these nucleo-side RT inhibitors (NRTI) as a cornerstone ofantiretroviral therapy.

TL;DR: It is postulate that the mitochondrial toxicity of the nucleoside-analogue reverse-transcriptase inhibitors plays an essential part in the development of this lipodystrophy, similar to the role of mitochondrial defects in theDevelopment of multiple symmetrical lipomatosis.

TL;DR: The profile of patients in the Netherlands infected with HIV is changing, with increasing numbers of older patients with multiple morbidities, which means that, in the near future, HIV care will increasingly need to draw on a wide range of medical disciplines, in addition to evidence-based screening and monitoring protocols to ensure continued high-quality care.

TL;DR: The life expectancy of asymptomatic HIV-infected patients who are still treatment-naive and have not experienced a CDC-B or C event at 24 weeks after diagnosis approaches that of non- Infected individuals, however, follow-up time is short compared to the expected number of years lived.

TL;DR: Survival probabilities were high among HIV-infected patients initiating HAART at an early stage of infection, and the best therapy strategy is therefore to startHAART at this stage of infections, however, deferring HAART in patients with high CD4 cell counts may be clinically more appropriate given toxicity and adherence problems.