K
Keiji Inoue
Researcher at Kōchi University
Publications - 229
Citations - 6025
Keiji Inoue is an academic researcher from Kōchi University. The author has contributed to research in topics: Cancer & Bladder cancer. The author has an hindex of 36, co-authored 201 publications receiving 5337 citations. Previous affiliations of Keiji Inoue include University of Texas MD Anderson Cancer Center.
Papers
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Journal Article
Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice.
Paul Perrotte,Takashi Matsumoto,Keiji Inoue,Hiroki Kuniyasu,Beryl Y. Eve,Daniel J. Hicklin,Robert Radinsky,Colin P.N. Dinney +7 more
TL;DR: Therapy with anti-EGFR MAb C225 has a significant antitumor effect mediated, in part, by inhibition of angiogenesis, and down-regulation of these angiogenic factors preceded the involution of blood vessels.
Journal Article
Interleukin 8 Expression Regulates Tumorigenicity and Metastases in Androgen-independent Prostate Cancer
Keiji Inoue,Joel W. Slaton,Beryl Y. Eve,Sun Jin Kim,Paul Perrotte,M. Derya Balbay,Seiji Yano,Menashe Bar-Eli,Robert Radinsky,Curtis A. Pettaway,Colin P.N. Dinney +10 more
TL;DR: It is demonstrated that IL-8 expression regulates angiogenesis in prostate cancer, in part by induction of MMP-9 expression, and subsequently regulates the growth and metastasis of human prostate cancer.
Journal Article
Interferon-α-mediated Down-Regulation of Angiogenesis-related Genes and Therapy of Bladder Cancer Are Dependent on Optimization of Biological Dose and Schedule
TL;DR: The data suggest that the antiangiogenic activity of IFN-alpha is dependent on frequent administration of optimal biological dose and not maximal tolerated dose, and that higher doses of IFn-alpha failed to produce significant antiangIogenic effects.
Journal Article
Paclitaxel Enhances the Effects of the Anti-Epidermal Growth Factor Receptor Monoclonal Antibody ImClone C225 in Mice with Metastatic Human Bladder Transitional Cell Carcinoma
Keiji Inoue,Joel W. Slaton,Paul Perrotte,Darren W. Davis,Christiane J. Bruns,Daniel J. Hicklin,David J. McConkey,Paul Sweeney,Robert Radinsky,Colin P.N. Dinney +9 more
TL;DR: Therapy with paclitaxel increases the ability of C225 to inhibit tumorigenicity and metastasis, mediated by inhibition of angiogenesis and induction of apoptosis.
Journal Article
Interleukin 8 expression regulates tumorigenicity and metastasis in human bladder cancer.
Keiji Inoue,Joel W. Slaton,Sun Jin Kim,Paul Perrotte,Beryl Y. Eve,Menashe Bar-Eli,Robert Radinsky,Colin P.N. Dinney +7 more
TL;DR: It is demonstrated that IL-8 expression enhances angiogenic activity through the induction of matrix metalloproteinase type 9 and subsequently regulates the tumorigenesis and production of spontaneous metastases of human TCC.