Keith A. Baggerly

TL;DR: Tumors characterized by the low expression of e-cadherin and the high expression of DNA α-topoisomerase II had a high propensity for distant metastasis and were associated with poor survival, and genes controlling cellular and stromal interactions were altered in the nonpapillary cancer.

TL;DR: The data support the conclusion that ZKSCAN3 induction represents a mechanism by which myeloma cells can induce cyclin D2 dysregulation, and contribute to disease pathogenesis.

TL;DR: FAK may be a unique therapeutic target in EOC given the dual anti-angiogenic and anti-metastatic potential of FAK inhibitors.

TL;DR: Establishing one epithelial and two mesenchymal cell lines from ascites of a bladder cancer patient demonstrated that the epithelial cells with surface expression of PD-L1, E-cadherin, CD24, and VEGFR2 rapidly formed tumors outside the primary tumor microenvironment in nude mice, exhibited signatures of immune evasion, increased stemness, increased calcium signaling, transformation, and novel E-c cadherin–RalBP1 interaction.

TL;DR: The results showed that targeting both the Src pathway and tubulin with KX-01 significantly inhibited tumor growth in preclinical mucinous ovarian cancer models, suggesting that this may be a promising therapeutic approach for patients with mucous ovarian carcinoma.