Keith B. Pfister

TL;DR: The structure guided optimization of a series of 2-morpholino, 4-substituted, 6-heterocyclic pyrimidines where the pharmacokinetic properties were improved by modulating the electronics of the 6-position heterocycle, and the overall druglike properties were fine-tuned further by modification of the 4-position substituent.

TL;DR: In this paper, the authors describe the use of 3-kinase inhibitors in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.

TL;DR: In this article, the authors proposed novel immune potentiators, novel vaccine adjuvants, novel compounds and pharmaceutical compositions, as well as novel methods for treating viral infections, including HCV, by administering the compounds and compositions.

TL;DR: In this article, the authors provided quinazoline compounds that are inhibitors of PDKl and pharmaceutical compositions including the compounds, and methods of treating proliferative diseases such as cancers, with the compounds or compositions.

TL;DR: In this paper, aryl-containing macrocyclic compounds were used for the inhibition of hepatitis C and SARS viral replication. But they were not suitable for the treatment of SARS.