K
Kenan A. J. Bozhueyuek
Researcher at Goethe University Frankfurt
Publications - 8
Citations - 126
Kenan A. J. Bozhueyuek is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Computer science & Peptide. The author has an hindex of 2, co-authored 6 publications receiving 65 citations. Previous affiliations of Kenan A. J. Bozhueyuek include Max Planck Society & Merck & Co..
Papers
More filters
Journal ArticleDOI
Modification and de novo design of non-ribosomal peptide synthetases using specific assembly points within condensation domains.
Kenan A. J. Bozhueyuek,Annabell Linck,Andreas Tietze,Janik Kranz,Frank Wesche,Sarah Nowak,Florian Fleischhacker,Yan-Ni Shi,Peter Grün,Helge B. Bode +9 more
TL;DR: A new fusion point inside the condensation domains of NRPSs is described that results in the development of the exchange unit condensation domain (XUC) concept, which enables the efficient production of peptides, even containing non-natural amino acids, in yields up to 280 mg l−1.
Posted ContentDOI
Synthetic Zippers as an Enabling Tool for Engineering of Non-Ribosomal Peptide Synthetases
TL;DR: This work describes a strategy to functionally combine NRPS fragments of Gram-negative and -positive origin, synthesising novel peptides at titres up to 290 mg l-1, and inserts synthetic zippers to split single protein NRPSs into up to three independently expressed and translated polypeptide chains.
Posted ContentDOI
Modification and de novo design of non-ribosomal peptide synthetases (NRPS) using specific assembly points within condensation domains
Kenan A. J. Bozhueyuek,Annabell Linck,Andreas Tietze,Frank Wesche,Sarah Nowak,Florian Fleischhacker,Helge B. Bode +6 more
TL;DR: A new fusion point inside condensation (C) domains of NRPSs is described that enables the efficient production of peptides, even containing non-natural amino acids, in yields higher than 280 mg/L.
Patent
Artificial non-ribosomal peptide synthetases
TL;DR: In this paper, a method for the modification and/or custom-made design of artificial non-ribosomal peptide synthetases (NRPSs) from naturally available NRPSs is presented.