J
Janik Kranz
Researcher at Goethe University Frankfurt
Publications - 2
Citations - 107
Janik Kranz is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Condensation domain & Peptide library. The author has an hindex of 1, co-authored 2 publications receiving 59 citations.
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Journal ArticleDOI
Modification and de novo design of non-ribosomal peptide synthetases using specific assembly points within condensation domains.
Kenan A. J. Bozhueyuek,Annabell Linck,Andreas Tietze,Janik Kranz,Frank Wesche,Sarah Nowak,Florian Fleischhacker,Yan-Ni Shi,Peter Grün,Helge B. Bode +9 more
TL;DR: A new fusion point inside the condensation domains of NRPSs is described that results in the development of the exchange unit condensation domain (XUC) concept, which enables the efficient production of peptides, even containing non-natural amino acids, in yields up to 280 mg l−1.
Posted ContentDOI
Influence of condensation domains on activity and specificity of adenylation domains
TL;DR: The role of the C-A interface, termed 9extended gatekeeping9, due to structural features of C domains, can also be transferred to other non-ribosomal peptide synthetases by engineering as discussed by the authors.