K
Kendra P. Rumbaugh
Researcher at Texas Tech University Health Sciences Center
Publications - 127
Citations - 7863
Kendra P. Rumbaugh is an academic researcher from Texas Tech University Health Sciences Center. The author has contributed to research in topics: Pseudomonas aeruginosa & Biofilm. The author has an hindex of 44, co-authored 121 publications receiving 6420 citations. Previous affiliations of Kendra P. Rumbaugh include University of Texas at Austin & Texas Tech University.
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Journal ArticleDOI
Contribution of quorum sensing to the virulence of Pseudomonas aeruginosa in burn wound infections
TL;DR: The burned-mouse model is used to examine the contribution of quorum-sensing systems to the pathogenesis of P. aeruginosa infections in burn wounds and suggests that theQuorum-Sensing systems play an important role in the horizontal spread ofP.
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Biofilm maturity studies indicate sharp debridement opens a time- dependent therapeutic window.
Randall D. Wolcott,Kendra P. Rumbaugh,Garth A. James,Gregory S. Schultz,Priscilla L. Phillips,Qingping Yang,Chase Watters,Philip S. Stewart,Scot E. Dowd +8 more
TL;DR: The principles of biofilm-based wound care, along with the use of serial debridement to continually remove mature biofilm, followed by biofilm wound management strategies, including topical antibiotics while the bioburden is still immature and more susceptible, are valid.
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Polyphosphate kinase is essential for biofilm development, quorum sensing, and virulence of Pseudomonas aeruginosa
M. Harunur Rashid,Kendra P. Rumbaugh,Luciano Passador,David G. Davies,Abdul N. Hamood,Barbara H. Iglewski,Arthur Kornberg +6 more
TL;DR: The conservation of PPK among many bacterial pathogens and its absence in eukaryotes suggest that PPK might be an attractive target for antimicrobial drugs.
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An In Vivo Polymicrobial Biofilm Wound Infection Model to Study Interspecies Interactions
Trevor Dalton,Scot E. Dowd,Randall D. Wolcott,Yan Sun,Chase Watters,John A. Griswold,Kendra P. Rumbaugh +6 more
TL;DR: It is observed that wounded mice given multispecies biofilm infections displayed a wound healing impairment over mice infected with a single-species of bacteria, and the bacteria in the polymicrobial wound infections displayed increased antimicrobial tolerance in comparison to those in single species infections.
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Synergistic Interactions of Pseudomonas aeruginosa and Staphylococcus aureus in an In Vitro Wound Model
Stephanie DeLeon,Allie Clinton,Haley Fowler,Jake Everett,Alexander R. Horswill,Kendra P. Rumbaugh +5 more
TL;DR: In this article, the authors describe a simple and clinically relevant in vitro wound model that supported concomitant growth of Pseudomonas aeruginosa and Staphylococcus aureus.