K
Kenji Takabayashi
Researcher at University of California, San Diego
Publications - 62
Citations - 6785
Kenji Takabayashi is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Immune system & Antigen. The author has an hindex of 30, co-authored 62 publications receiving 6669 citations. Previous affiliations of Kenji Takabayashi include Novartis.
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Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers
TL;DR: Polymerase chain reaction and Southern blot analysis confirmed the frequent deletion or rearrangement of the CDK4-inhibitor gene in melanomas, gliomas, lung cancers and leukaemias, and the absence of detectable gene transcripts.
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Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis.
Daniel Rachmilewitz,Kyoko Katakura,Fanny Karmeli,Tomoko Hayashi,Constantin Reinus,Bernard Rudensky,Shizuo Akira,Kiyoshi Takeda,Jongdae Lee,Kenji Takabayashi,Eyal Raz +10 more
TL;DR: The protective effects of Probiotics are mediated by their own DNA rather than by their metabolites or ability to colonize the colon, and live microorganisms are not required to attenuate experimental colitis because nonviable probiotics are equally effective.
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Conjugation of immunostimulatory DNA to the short ragweed allergen Amb a 1 enhances its immunogenicity and reduces its allergenicity
H Tighe,Kenji Takabayashi,David A. Schwartz,Gary Van Nest,Stephen Tuck,Joseph Eiden,Anne Kagey-Sobotka,Peter S. Creticos,Lawrence M. Lichtenstein,Hans L. Spiegelberg,Eyal Raz +10 more
TL;DR: Amb a 1-ISS conjugate has an enhanced T(H)1-biased immunogenicity and reduced allergenicity, and may offer a more effective and safer approach for allergenic immunotherapy than currently available methods.
Journal Article
Inhibition of TNF-alpha expression by adenosine: role of A3 adenosine receptors.
TL;DR: In this article, the authors studied the human macrophage cell line U937 to determine the adenosine receptor subtypes responsible and the intracellular signaling mechanisms involved.
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Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis
Daniel Rachmilewitz,Fanny Karmeli,Kenji Takabayashi,Tomoko Hayashi,Leonor Leider-Trejo,Jongdae Lee,Lorenzo M. Leoni,Eyal Raz +7 more
TL;DR: In all models of experimental and spontaneous colitis examined, ISS-ODN administration ameliorated clinical, biochemical, and histologic scores of colonic inflammation and suggest a physiologic, anti-inflammatory role for immunostimulatory DNA in the GI tract.