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Kennedy W. Gilchrist

Researcher at University of Wisconsin-Madison

Publications -  72
Citations -  4615

Kennedy W. Gilchrist is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 32, co-authored 72 publications receiving 4524 citations. Previous affiliations of Kennedy W. Gilchrist include Oklahoma State University Center for Health Sciences & City of Hope National Medical Center.

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HER-2/neu in node-negative breast cancer: prognostic significance of overexpression influenced by the presence of in situ carcinoma.

TL;DR: Overexpression of HER-2/neu is associated with poor clinical outcome in a subset of node-negative patients with small, ER-positive, predominantly invasive tumors and may play a role in resistance to adjuvant chemotherapy.
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Overexpression of HER-2/neu and its relationship with other prognostic factors change during the progression of in situ to invasive breast cancer.

TL;DR: The results are consistent with the hypothesis that HER-2/neu plays a more important role in initiation than in progression of ductal carcinomas and suggest that overexpression decreases within individual tumors as they evolve from in situ to increasingly invasive lesions.
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Efficacy of Adjuvant Chemotherapy in High-Risk Node-Negative Breast Cancer

TL;DR: Adjuvant chemotherapy with six cycles of cyclophosphamide, methotrexate, fluorouracil, and prednisone is effective in improving three-year disease-free survival among high-risk patients with axillary-node-negative, operable breast cancer.
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Identification of a subgroup of patients with breast cancer and histologically positive axillary nodes receiving adjuvant chemotherapy who may benefit from postoperative radiotherapy.

TL;DR: A potential for improved survival in this subset of patients with the addition of postmastectomy radiation to chemotherapy is suggested, and the presence of a group of patients at high risk for isolated LR recurrence despite adjuvant chemotherapy is emphasized.