Kenneth B. Larson

TL;DR: The data demonstrate the feasibility of accurately measuring brain permeability of highly diffusible substances by this technique and show that neither water nor the alcohols studied freely equilibrate with brain when the cerebral blood flow exceeds 30 ml/100 g min-1.

TL;DR: The results indicate that the adoption of simplifying assumptions for operational convenience can lead to substantial errors and must be done with caution and present simple new analytical solutions of the tracer conservation equations describing the complete, unsimplified three-compartment model.

TL;DR: It is concluded that a two-barrier distributed-parameter has the potential of serving as a substitute for the Kety model in PET measurements of CBF in patients, especially when scan durations for T > 1 min are desired.

TL;DR: The radiopharmaceutical glucose--11C was used in vivo measurement of brain-glucose transport kinetics and metabolism in the rhesus monkey and a highlysignificant correlation was found between the two methods of measuring CMRGlc.

TL;DR: In computing the mean transit time for the intravascular tracer, the conventional Hamilton extrapolation of the downslope of the recording obtained for the washout of the tracer from the brain subsequent to an intracarotid bolus injection was found to be inadequate, yielding a means transit time that systematically underestimated that parameter.