K
Kenneth G. Holden
Researcher at Smith, Kline & French
Publications - 65
Citations - 1619
Kenneth G. Holden is an academic researcher from Smith, Kline & French. The author has contributed to research in topics: Lactam & Total synthesis. The author has an hindex of 19, co-authored 65 publications receiving 1598 citations.
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Journal ArticleDOI
Modification of the hydroxy lactone ring of camptothecin: inhibition of mammalian topoisomerase I and biological activity.
Robert P. Hertzberg,Mary Jo Caranfa,Kenneth G. Holden,Dalia R. Jakas,Gregory Gallagher,Michael R. Mattern,Shau Ming Mong,J O Bartus,Randall K. Johnson,William D. Kingsbury +9 more
TL;DR: The present findings, as well as other reports that the hydroxy lactone ring of camptothecin is critical for antitumor activity in vivo, correlate with the structure-activity relationships at the level of topoisomerase I and support the hypothesis that antitumors activity is related to inhibition of this target enzyme.
Journal ArticleDOI
Pyrrolo[1,4]benzodiazepine antitumor antibiotics: relationship of DNA alkylation and sequence specificity to the biological activity of natural and synthetic compounds.
Laurence H. Hurley,Teri Reck,David E. Thurston,David R. Langley,Kenneth G. Holden,Robert P. Hertzberg,John R. E. Hoover,Gregory Gallagher,Leo F. Faucette +8 more
TL;DR: It is determined that the degree of saturation in the five-membered ring of the P(1,4)Bs has a significant effect on the DNA bonding reactivity and biological activity of this class of compounds.
Journal ArticleDOI
Identification and quantitation of alditol acetates of neutral and amino sugars from mucins by automated gas-liquid chromatography.
Lee J. Griggs,Alex Post,E.R. White,Joseph Alan Finkelstein,W.E. Moeckel,Kenneth G. Holden,J.E. Zarembo,Jerry A. Weisbach +7 more
TL;DR: An automated GLC method has been described that allows easy identification and quantitation on a single column of the alditol acetates of the commonly occurring neutral and amino sugars found in epithelial mucins on a new high-temperature stable column.