Kenneth W. Hill

TL;DR: An improved method was developed utilizing a streamlined method for the preparation of phosphoramidite monomers and a single-step deprotection of the resulting oligoribonucleotide product using 1,2-diamines under anhydrous conditions and it was demonstrated that the chemical synthesis of RNA can be as simple and robust as thechemical synthesis of DNA.

TL;DR: In this article, an approach for reversibly conjugating an oligonucleotide was proposed, which includes obtaining an oligoneucleotide labeled with a diene moiety and a target entity labeled with dienophile moiety, and heating the oligoneuclidean to a solution at a first temperature to effect Diels Alder reaction to produce a conjugate.

TL;DR: An oligonucleotide derivative having the structure of formula (A) and methods for preparing the oligon nucleotide derivative are disclosed in this paper, where an amino or thiol group is added to the first oligonotide derivative.

TL;DR: In this article, the authors provide methods of conjugating oligonucleotides using a squarate reagent to produce an activated first oligonotide, and binding the first and second oligon nucleosides to a splint splint.

TL;DR: In this paper, an oligonucleotide derivative having the structure of formula (A) and methods for preparing the oligon nucleotide derivative are disclosed, wherein R3 is a first oligonotide; R1 is selected from the group consisting of alkyl, cycloalkyl, aryl, heterocyclyl, and heteroaryl, a polyethylene glycol, a peptide, a protein, polysaccharide, and a second oligoneotide.