K
Kerst-Jan Hijlkema
Researcher at University Medical Center Groningen
Publications - 1
Citations - 1178
Kerst-Jan Hijlkema is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: Autophagy. The author has an hindex of 1, co-authored 1 publications receiving 711 citations.
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Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion.
Mario Mauthe,Idil Orhon,Cecilia Rocchi,Xingdong Zhou,Morten Luhr,Kerst-Jan Hijlkema,Robert P. Coppes,Nikolai Engedal,Muriel Mari,Fulvio Reggiori +9 more
TL;DR: It is shown that CQ mainly inhibits autophagy by impairing autophagosome fusion with lysosomes rather than by affecting the acidity and/or degradative activity of this organelle.