K
Kevin J. Martin
Researcher at Washington University in St. Louis
Publications - 62
Citations - 2786
Kevin J. Martin is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Parathyroid hormone & Secondary hyperparathyroidism. The author has an hindex of 25, co-authored 62 publications receiving 2752 citations. Previous affiliations of Kevin J. Martin include Veterans Health Administration.
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Journal ArticleDOI
Marked suppression of secondary hyperparathyroidism by intravenous administration of 1,25-dihydroxy-cholecalciferol in uremic patients.
Eduardo Slatopolsky,Carol Weerts,J Thielan,Ronald L. Horst,Herschel R. Harter,Kevin J. Martin +5 more
TL;DR: In conclusion, the use of intravenous 1,25(OH)2D3 administered intravenously rather than orally may result in a greater delivery of the vitamin D metabolite to peripheral target tissues other than the intestine and allow a greater expression of biological effects of 2D3 in peripheral tissues.
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Phosphorus restriction reverses hyperparathyroidism in uremia independent of changes in calcium and calcitriol.
TL;DR: Reduction in dietary Pi in advanced renal insufficiency improves secondary hyperparathyroidism by a mechanism that is independent of the levels of calcitriol or plasma ICa, as well as in the absence of a concomitant increase in levels of ICa or calcitril.
Journal ArticleDOI
The noncalcemic analogue of vitamin D, 22-oxacalcitriol, suppresses parathyroid hormone synthesis and secretion.
Alex J. Brown,Cindy Ritter,Jane Finch,Jeremiah J. Morrissey,Kevin J. Martin,E Murayama,Yasuho Nishii,Eduardo Slatopolsky +7 more
TL;DR: Using a probe prepared by random prime labeling of an Msp I fragment of plasmid PTHm122, it is found that a single 40-ng dose of OCT or 1,25-(OH)2D3 depressed PTH mRNA levels by 70-80% by 48 h when compared with vehicle, indicating that OCT is a very effective suppressor of PTH secretion with virtually no calcemic activity.
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Impaired parathyroid hormone metabolism in patients with chronic renal failure.
Jeffrey J. Freitag,Kevin J. Martin,Keith A. Hruska,Charles H. Anderson,Mollie Conrades,Jack H. Ladenson,Saulo Klahr,Eduardo Slatopolsky +7 more
TL;DR: Secondary hyperparathyroidism, with markedly elevated levels of circulating parathyroid hormone, is a universal complication of chronic renal failure.
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Minerals, vitamin D, and parathyroid hormone in continuous ambulatory peritoneal dialysis
TL;DR: Unlike chronic hemodialysis, continuous ambulatory peritoneal dialysis removes significant amounts of parathyroid hormone and Substantial amounts of phosphorus are removed but not to an extent that precludes use of phosphorus binders.