K
Kevin P. Cusack
Researcher at Rensselaer Polytechnic Institute
Publications - 4
Citations - 95
Kevin P. Cusack is an academic researcher from Rensselaer Polytechnic Institute. The author has contributed to research in topics: Lanosterol & Monooxygenase. The author has an hindex of 3, co-authored 4 publications receiving 84 citations.
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Sulfonylation of organometallic reagents with arenesulfonyl fluorides: a simple one-step synthesis of sulfones
Journal ArticleDOI
32-Methyl-32-oxylanosterols: dual-action inhibitors of cholesterol biosynthesis
TL;DR: Three 32-methylated analogs of the intermediates generated during the removal of the 14 alpha-methyl group by P-450DM, compounds 17a, 17b, and 18, have been prepared and their biochemical activities assessed and all three compounds were found to be direct inhibitors of P- 450DM.
Journal ArticleDOI
Oxolanosterol oximes: dual-action inhibitors of cholesterol biosynthesis.
TL;DR: It is demonstrated that 15-oxime XIX is indeed a dual-action inhibitor of cholesterol biosynthesis which causes both the inhibition of P450DM and a reduction in HMGR activity.