Showing papers in "Journal of Lipid Research in 1994"

TL;DR: Considerable additional research is needed in order to fully understand both normal lipolytic regulation and the abnormalities of lipolysis which accompany pathological conditions.

TL;DR: MRI is shown to be an accurate and precise technique to evaluate adipose tissue mass in subcutaneous and intraabdominal compartments and was found to be a valid method to separately evaluate the mass of intraABdominal subcompartments of intra peritoneal and retroperitoneal adipose tissues.

TL;DR: In this paper, positive and negative ion electrospray mass spectrometry (MS) and MS/MS were used to identify glycerophospholipid and ceramide headgroups and their alkyl, alkenyl and acyl constituents.

TL;DR: Data indicate that polyunsaturated fatty acids coordinately regulate the expression of several enzymes involved in carbohydrate and lipid metabolism and the mechanism of control does not require extrahepatic factors or fatty acid metabolism.

TL;DR: A ceramide previously known to constitute 25% of the extractable human stratum corneum ceramides has been found to contain the same novel sphingoid base, amide-linked to long-chain alpha-hydroxyacids.

TL;DR: To model one of the steps in the possible mechanism of atherogenesis, the cytotoxicity of LDL- was demonstrated to be greater against subconfluent than confluent aortic endothelial cells.

TL;DR: The evidence for and against the differential absorption of cholesterol from dietary and biliary sources is examined.

TL;DR: Hormone-sensitive lipase (HSL) mediates the lipolysis of triacylglycerol from mammalian adipocytes, resulting in the release of non-esterified fatty acids and glycerol and the measurement of HSL mRNA levels in response to hormonal regulators was studied.

TL;DR: In the Framingham Offspring Study as mentioned in this paper, apolipoprotein (apo) B, the major protein constituent of LDL, was measured in 1,533 men and 1,597 women.

TL;DR: Evidence suggests that HMGR is an important control point for the synthesis of many of these plant isoprenoids, including some that are vital for primary metabolism and pest resistance, and may also have a role in regulation of plant HMGR.

TL;DR: In both men and women, triglycerides, body mass index (BMI), and alcohol intake contributed significantly to HDL cholesterol and apoA-I variability.

TL;DR: A potential link observed in vivo between an increase in fatty acid supply induced by high-fat or high-carbohydrate diets and the hyperplastic development of adipose tissue is provided.

TL;DR: The results present the possibility that overexpression of the apoC-III gene could contribute to the hypertriglyceridemia observed in IDDM, and suggest that the apOC- III transcriptional changes seen in animals are caused by differences in insulin concentrations.

TL;DR: The precision of this analytical SDS-PAGE-based procedure to determine the plasma concentrations of apoB-100 and B-48 in triglyceride-rich lipoproteins was found to be appreciably low.

TL;DR: Findings show that cafestol is at least partly responsible for the cholesterol-raising effect of boiled coffee, and that Norwegians who habitually consumed 5-9 cups of boiling coffee per day had higher serum cholesterol levels and lower GGT but no higher alanine aminotransferase activity than controls.

TL;DR: Data suggest a critical role of the assay methodology in the reproducibility of measured Lp[a] and apolipoprotein plasma concentrations and recommend the examination of each system for measurement of long-term stored plasma samples.

TL;DR: It is confirmed that, at least in hypercholesterolemic men, a modest increase in palmitic acid raises LDL cholesterol relative to oleic acid, even when dietary cholesterol is low (< 165 mg/day).

TL;DR: The reproducibility and accuracy of the method are within the requirements of the CDC-NHLBI (Centers for Disease Control-National Heart, Lung, and Blood Institute) Lipid Standardization Program.

TL;DR: Data indicate that apoE phenotype modulates the LDL cholesterol-lowering response to a diet meeting NCEP Step 1 criteria, and that male subjects carrying the apo E4 allele are more responsive than other subjects.

TL;DR: It is concluded that hepatic lipase facilitates, but is not essential for, the initial uptake of chylomicron remnants by rat liver, and that endocytosis of chyomaticron remnants does not require binding to hepaticlipase or the associated hydrolysis of remnant lipids.

TL;DR: It was determined that the serum fatty acid ethyl ester concentration began to decrease within 2 h of the time ethanol ingestion had been stopped, and there was a higher percentage of saturated fatty acids in the FAEE pool than in the serum free fatty acid and triglyceride pools.

TL;DR: The modified dual-isotope plasma ratio method described here provides a simpler and more physiologic approach to the routine measurement of cholesterol absorption in the hamster and similar small animal models.

TL;DR: Addition of cAMP or S58035 to cholesterol-loaded J774 cells did enhance efflux of radiolabeled cholesterol from apoE secreting compared to non-secreting macrophages but did not detectably alter cellular free cholesterol or cholesteryl ester mass.

TL;DR: The "first pass" effect of oral estradiol on the liver and/or intestine appears to increase HDL apoA-I levels (particularly in HDL2) by increasing HDL apOA- I production, and not by reducing HDL api-I catabolism.

TL;DR: CETP-mediated transfers of cholesteryl esters from HDL to VLDL and LDL are accompanied not only by a reduction in HDL size but also by the progressive dissociation from HDL of a pool of prebeta-migrating, essentially lipid-free apoA-I.

TL;DR: The interaction of lipoxygenases of different positional specificities with human lipoproteins is studied and it is found that the arachidonate 15-lipoxygenase of rabbit and humans and the archidonate 12-lip oxygenate lipoprotein of porcine leukocytes oxygenatelipoprotein as indicated by the formation of oxygenated lipids and changes in electrophoretic mobility of low density lipop protein.

TL;DR: Data indicate that multiple, lipid-derived species exist in oxidized LDL that can contribute to the release of IL-1 beta, a process that may contribute to atherogenesis.

TL;DR: Lysosomal accumulation of free cholesterol in macrophages after phagocytic uptake and hydrolysis of cholesteryl ester droplets leads to the formation of cholesterol monohydrate crystals within lipid-filled lysosomes.

TL;DR: The data suggest that mutations in the LPL gene that cause partial LPL deficiency might be a frequent factor in the pathogenesis of pregnancy-induced chylomicronemia.