K
Khadeja-Tul Kubra
Researcher at University of Louisiana at Monroe
Publications - 31
Citations - 408
Khadeja-Tul Kubra is an academic researcher from University of Louisiana at Monroe. The author has contributed to research in topics: Medicine & ARDS. The author has an hindex of 9, co-authored 20 publications receiving 206 citations.
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Journal ArticleDOI
GHRH antagonists support lung endothelial barrier function.
Mohammad A. Uddin,Mohammad S. Akhter,Sitanshu S. Singh,Khadeja-Tul Kubra,Andrew V. Schally,Seetharama D. Jois,Nektarios Barabutis +6 more
TL;DR: GHRH antagonists should be considered as promising therapeutic agents for treating severe respiratory abnormalities, such as the lethal Acute Respiratory Distress Syndrome (ARDS), and support the evidence for the anti – inflammatory role of G HRH antagonists in the vasculature.
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Hsp90 inhibitors induce the unfolded protein response in bovine and mice lung cells.
TL;DR: It is demonstrated that Hsp90 inhibition triggers the activities of the unfolded protein response, and it is suggested that this molecular machinery contributes in the protective action of Hsp 90 inhibitors in the lung microvasculature.
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Unfolded protein response in cardiovascular disease
TL;DR: Since UPR is consisted of three distinct elements, namely the activating transcription factor 6, the protein kinase RNA-like ER kinase; and the inositol-requiring enzyme-1α, a highly orchestrated manipulation of those molecular branches may provide new therapeutic possibilities against the severe outcomes of cardiovascular disease.
Journal ArticleDOI
Effects of Heat Shock Protein 90 Inhibition In the Lungs.
Mohammad A. Uddin,Khadeja-Tul Kubra,Jafrin Jobayer Sonju,Mohammad S. Akhter,Jois Seetharama,Nektarios Barabutis +5 more
TL;DR: It is suggested that the barrier protective effects of Hsp90 inhibition in the lung microvasculature are highly probable to be associated with the activation of the UPR and the development of novel compounds which stochastically capacitate the repairing elements of UPR may deliver new therapeutic possibilities against the severities of the acute respiratory distress syndrome.
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P53 versus inflammation: an update.
TL;DR: The purpose of the present article is to provide an update on the mechanisms enforcing the protective actions of P53 in human homeostasis, and to discuss current efforts on the development of new therapies against inflammatory abnormalities.